Optimization of the extraction process of Artemisia rupestris L. by AHP method combined with Response Surface Methodology

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Author: Zhen-Dong CHEN Yang SHI  Deng-Feng FAN Hui-Kang MA Dong-Bo XIE

Affiliation: Department of Pharmacy, Integrated Chinese and Western Medicine Hospital of Karamay (Karamay Municipal Peoples Hospital), Karamay 834000, Xinjiang, China

Keywords: Artemisia rupestris L. Extraction technology Response surface methodology Analytic hierarchy process Content determination

DOI: 10.19960/j.issn.1005-0698.202304008

Reference: Zhen-Dong CHEN, Yang SHI, Deng-Feng FAN, Hui-Kang MA, Dong-Bo XIE.Optimization of the extraction process of Artemisia rupestris L. by AHP method combined with Response Surface Methodology,2023, 32(4): 426-433.DOI: 10.19960/j.issn.1005-0698.202304008.[Article in Chinese]  Copied

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Abstract

Objective To optimize the extraction process of Artemisia rupestris L. by analytic hierarchy process method and response surface methodology.

Methods On the basis of univariate optimum seeking method combined with response surface methodology, the three main factors of extraction times, solvent multiples and extraction time were in-vestigated. With the content and the extract rate of luteolin, apigenin and rupestonic acid as indexes, the weight coefficient was calculated by analytic hierarchy process method. Then the extraction process of rupestris was optimized by comprehensive score.

Results The extraction process of rupestris was as follows: heated reflux extraction with 10 times of 60% ethanol for 3 times, 1 hour each time.

Conclusion The optimized extraction conditions were simple and reproducible, which was suitable for the extraction of Artemisia rupestris L..

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References

1.崔凤侠, 章宸, 姜勇, 等. 新疆一枝蒿乙酸乙酯部位化学成分研究[J].中国中药杂志, 2013, 38(11): 1757-1759. [Cui FX, Zhang C, Jiang Y, et al. Chemical constituents from ethyl acetate extract of Artemisia rupestri[J]. China Journal of Chinese Materia Medica, 2013, 38(11): 1757-1759.] DOI: 10.4268/cjcmm20131122.

2.张素挽, 杨璐, 顾政一, 等. 新疆一枝蒿化学成分的研究[J]. 新疆医科大学学报, 2016, 39(4): 408-410. [Zhang SW, Yang L, Gu ZY, et al. Studies on chemical constituents of Artemisia rupestris L[J]. Journal of Xin Jiang Medical University, 2016, 39(4): 408-410.] DOI: 10.3969/j.issn. 1009-5551.2016.04.006.

3.顾冬雨. LC-MS研究一枝蒿药材及制剂的化学成分和一枝蒿酮酸的代谢产物[D]. 新疆: 中国科学院大学(新疆), 2012.

4.赵宗政. 新疆一枝蒿化学成分的研究[D]. 南京: 南京大学(南京), 2012.

5.贺飞. 新疆一枝蒿化学成分及HPLC指纹谱图研究[D].新疆: 中国科学院大学(新疆), 2012.

6.Gu D, Yang Y, Chen Q, et al. Identification of metabolites of rupestonic acid inra-turine by liquid chromatography combined with electrospray ionizationquadr-upoletime-of-flight tandem mass spec-trometry[J]. Biomed Chromatogr, 2015, 29(4): 595-603. DOI: 10.1002/bmc.3319.

7.Gu D, Yang Y, Abdulla R, et al. Characterization and identification of chemical comp-ositions in the extract of Artemisia rupestris L. by liquid chromatography coup-led to quadrupole time-of-flight tandem mass spectrometry[J].Rapid Commun Mass Spectrom, 2012, 26(1): 83-100. DOI: 10.1002/rcm.5289.

8.Yang Y, Gu D, Yili A, et al. One-step separation and purification of rupestonic acid and chrysosptertin B from Artemisia rupestris L. by high-speed counter-current chromatography[J]. Phytochem Anal, 2010, 21(2): 205-209. DOI: 10.1002/pca.1169.

9.兰冬冬, 朱国强, 郭雄飞, 等. 不同生长期一枝蒿中3种化学成分的含量测定[J]. 中医药学报, 2017, 45(6): 24-27. [Lan DD, Zhu GQ, Guo XF, et al. Contents determination of three chemical constituents in Artemisia rupestris L. at different growth stages[J]. Acta Chinese Medicine and Pharmacology, 2017, 45(6): 24-27.] DOI: 10.3969/j.issn.1002-2392.2017.06.007.

10.夏少立, 曹悦, 李庆林, 等. 新疆一枝蒿的化学成分研究[J].中草药, 2020, 51(13): 3393-3398. [Xia SL, Cao Y, Li QL, et al. Chemical constituents of Artemisia rupestris[J]. Chinese Traditional and Herbal Drugs, 2020, 51(13): 3393-3398.] DOI: 10.7501/j.issn.0253-2670. 2020.13.005.

11.蔡晓翠, 毛艳, 贺金华, 等. 新疆一枝蒿不同极性部位体外抗炎作用的谱-效关系分析[J]. 药物分析杂志, 2019, 39(9): 1580-1589. [Cai XC, Mao Y, He JH, et al. Spectrum-activity relationship of anti-inflammatory effect in vitro of different polar parts of Artemisia rupestris L[J]. Chinese Journal of Pharmaceutical Analysis, 2019, 39(9): 1580-1589.] DOI:10.16155/j.0254-1793.2019.09.06

12.新疆维吾尔自治区食品药品监督管理局. 新疆维吾尔自治区中药维吾尔药材饮片炮制规范, 第1册[S].2010: 283.

13.田红林, 马英, 轩辕欢, 等. HPLC测定岩蒿茎、花、叶中一枝蒿酮酸、蒙花苷、木犀草素的含量[J].中药材, 2016, 39(11): 2566-2568. [Tian HL, Ma Y, Xuan YH, et al. Determination of artesunic acid,linarin and luteolin in stems, flowers and leaves of Artemisia scoparia by HPLC[J]. Journal of Chinese Medicinal Materials, 2016, 39(11): 2566-2568.] DOI: 10.13863/j.issn1001-4454.2016.11.032.

14.陈振东, 毛艳, 顾政一, 等. 复方一枝蒿滴鼻剂提取工艺的优化[J].中成药, 2018, 40(4): 957-961. [Chen ZD, Mao Y, Gu ZY, et al. Optimization of extraction process of Compound Artemisia Rhinodrops[J]. Chinese Tradi-tional Patent Medicine, 2018, 40(4): 957-961.] DOI: 10.3969/j.issn.1001-1528.2018.04.040.

15.毛艳, 陈振东, 顾政一, 等. 多指标综合评分法优选芩蒿滴鼻剂的提取工艺[J].中国中医药信息杂志, 2018, 25(4): 82-86. [Mao Y, Chen ZD, Gu ZY, et al. Optimization of extraction technology for qinhao nasal drops by multi-index comprehen-sive evaluation method[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2018, 25(4): 82-86.] DOI: 10.3969/j.issn.1005-5304.2018.04.017.