Efficacy and safety of bevacizumab biosimilars versus original drugs for patients with metastatic colorectal cancer: a Meta-analysis

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Author:  En-Hui WEN ¹ Ying LI ² Zhi-Ying WANG ³ Li-Hui LONG ¹

Affiliation: 1. Clinical Pharmaceutics Room, the First Afiliated Hospital of Xi’an Medical University, Xi’an 710077, China 2. Department of Traditional Chinese Medicine, Xi’an Mental Health Center, Xi’an 710061, China 3. College of Pharmacy, Xi’an Medical University, Xi’an 710021, China

Keywords: Bevacizumab Biosimilar Metastatic colorectal cancer Meta-analysis Randomized controlled trial

DOI: 10.19960/j.issn.1005-0698.202312010

Reference: En-Hui WEN, Ying LI, Zhi-Ying WANG, Li-Hui LONG.Efficacy and safety of bevacizumab biosimilars versus original drugs for patients with metastatic colorectal cancer: a Meta-analysis[J].Yaowu Liuxingbingxue Zazhi,2023, 32(12):1401-1407.DOI: 10.19960/j.issn.1005-0698.202312010.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To systematically review the efficacy and safety of bevacizumab biosimilars versus original drugs in treatment of metastatic colorectal cancer.

Methods PubMed, Embase, Cochrane Library, CNKI, WanFang Data, VIP and SinoMed databases were electronically searched to collect the randomized controlled trials (RCTs) of bevacizumab biosimilar in patients with metastatic colorectal cancer from inception to June 18, 2023. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies, and a meta-analysis was conducted using Stata 17.0 software.

Results A total of 4 RCTs involving 1 052 patients were included. The results of meta-analysis showed that no significant difference was found in overall response rate (RD=﹣0.01, 95%CI ﹣0.06 to 0.05, P=0.86), progression free survival (HR=1.00, 95%CI 0.91 to 1.09, P=0.94), the total incidence of adverse drug reactions (RR=1.05, 95%CI 0.85 to 1.31, P=0.91) and the incidence of severe adverse events (RR=0.886, 95%CI 0.377 to 2.081, P=0.60) between bevacizumab biosimilars group and original drugs group.

Conclusion The current evidence shows that bevacizumab biosimilar is equivalent to original drugs in treatment of metastatic colorectal cancer. Due to limited quality and quantity of the included studies, more high quality studies are required to verify the above conclusions.

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References

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