Drug use evaluation of tranexamic acid and sodium chloride injection based on weighted TOPSIS method

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Author: Mei-Juan LI ¹ Xiu-Mei LIU ² Lei LI ³ Jian-Ping LIU ¹ Li-Qin LIU ¹ Qian XIANG ⁴  Jin-Hua ZHANG ⁵  Qing LI ¹

Affiliation: 1. Department of Pharmacy, First Hospital of Shanxi Medical University, Taiyuan 030001, China 2. Department of Pharmacy, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou 450003, China 3. Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan 030001, China 4. Department of Pharmacy, Peking University First Hospital, Beijing 100034, China 5. Department of Pharmacy, Fujian Maternity and Child Health Care Hospital, Fuzhou 350001, China

Keywords: Tranexamic acid and sodium chloride injection Weighted TOPSIS method Drug use evaluation

DOI: 10.19960/j.issn.1005-0698.202312001

Reference: Mei-Juan LI, Xiu-Mei LIU, Lei LI, Jian-Ping LIU, Li-Qin LIU, Qian XIANG,Jin-Hua ZHANG, Qing LI.Drug use evaluation of tranexamic acid and sodium chloride injection based on weighted TOPSIS method[J].Yaowu Liuxingbingxue Zazhi,2023, 32(12): 1321-1330.DOI: 10.19960/j.issn.1005-0698.202312001.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To establish the rules of drug use evaluation (DUE) of tranexamic acid and sodium chloride injection, and to provide a basis for clinical rational drug use.

Methods Based on the drug instruction and referring to relevant guidelines and literature, the DUE criteria were established, and the weighted TOPSIS method was used to evaluate the rationality of medical records discharged from the First Hospital of Shanxi Medical University from February to August 2022.

Results Among the 171 cases of medication regimen, there are were 66 cases (38.60%) close to the optimal regimen (C_i ≥0.8) (reasonable); C_i was between 0.6 and 0.8 (basically reasonable) in 73 cases (42.69%); and C_i <0.6 (unreasonable) in 32 cases (18.71%). The unreasonable phenomenon mainly appeared in adverse reaction monitoring, medication administered, indications and so on.

Conclusion The weighted TOPSIS method is used to evaluate the rationality of tranexamic acid and sodium chloride injection, and its evaluation results are more intuitive and convenient.

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