Acute attack of critical asthma caused by ketochromate tromethamine injection: a case report

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Affiliation: 1. Department of Pharmacy, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China 2. Department of Respiratory Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China

Keywords: Ketorolac tromethamine The elderly Bronchial asthma Adverse drug reactions

DOI: 10.19960/j.issn.1005-0698.202304014

Reference: Xu-Hui PU, Zheng-Ya WANG.Acute attack of critical asthma caused by ketochromate tromethamine injection: a case report[J].Yaowu Liuxingbingxue Zazhi,2023, 32(4): 476-480.DOI: 10.19960/j.issn.1005-0698.202304014.[Article in Chinese]  Copied

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Abstract

A 67-year-old male patient was given ketorolac tromethamine injection (90mg) and 0.9% sodium chloride injection (250 mL) intravenously once a day after the operation of the right incarcerated inguinal hernia. The patient had dyspnea and sweating at 120 minutes after the first administration, with a heart rate of 120 times/min and a respiration rate of 32 times/min. The patient’s blood oxygen saturation was 88% (nasal catheterization with oxygen at 3 L·min^-1), and was lethargic, with positive triplectral signs, audible laryngeal sounds, and loud wheezing sounds in both lungs. The diagnosis was an acute attack of severe bronchial asthma. The drug was stopped and the patient was treated with dexamethasone and aminophylline injections. After 1 hour, the patient's dyspnea improved. The heart rate was 102 times/min, the breathing rate was 28 times/min, the blood oxygen saturation was 100% (oxygen absorption by mask was 5 L·min^-1), and his consciousness was clear. After 1 day, the patient had no dyspnea, and no wheezing sound was heard in both lungs. By correlation analysis, the causal relationship between the acute asthma attack and ketorolac ambulatol injection was evaluated as "very possible".

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