Objective  To explore the effect of Buyang Huanwu decoction plus donepezil and individual cognitive training on the rehabilitation of patients with cognitive impairment after stroke (PSCI).

Methods  80 patients with PSCI admitted to our hospital were gathered and randomly grouped into a training group (n=40, conventional treatment + individualized cognitive training) and a combined group (n=40, used modified Buyang Huanwu decoction on the basis of the training group). The neurological function, cognitive function, hemorheological indexes, the levels of serum glial fibrillary acidic protein and homocysteine, quality of life and adverse reactions were compared between the two groups before treatment and after 12 weeks of treatment.

Results  After treatment, the Chinese Stroke Scale score, plasma viscosity, fibrinogen, hematocrit, and the levels of serum glial fibrillary acidic protein and homocysteine in both groups were lower than those before treatment (P<0.05), and the combined group were obviously lower than the training group (P<0.05); the scores of Mini-Mental State Examination and Stroke-Specific Quality of Life Scale in both groups were higher than those before treatment (P<0.05), and the combined group were obviously higher than the training group (P<0.05). There was no significant difference in the incidence of adverse reactions between the combined group of 5.00% and the training group of 10.00% (P>0.05).

Conclusion  The combination of Buyang Huanwu decoction plus modified formula, donepezil and individualized cognitive training intervention for PSCI patients can significantly reduce serum glial fibrillary acidic protein and homocysteine levels, effectively correct abnormal hemorheology, significantly improve neural function and cognitive function, and greatly improve the quality of life.

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