Establishment and application of drug use evaluation criteria of argatroban

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Author: DAI Hengfen ¹ ZHENG Caiyun ² LIU Yunchun ¹ ZHANG Hong ¹ LIU Maobai ³  ZHANG Jinghua ⁴

Affiliation: 1. Department of Pharmacy, Fuzhou First Hospital Affiliated with Fujian Medical University, Fuzhou 350009, China 2. Department of Clinical Pharmacy, Affiliated Fuqing Hospital of Fujian Medical University, Fuzhou 350300, China 3. Department of Pharmacy, Union Hospital Affiliated to Fujian Medical University, Fuzhou 350001, China 4. Department of Pharmacy, Fujian Maternity and Children Health Care Hospital, Fuzhou 350005, China

Keywords: Argatroban Drug use evaluation criteria Expert consultation method Rational drug use

DOI: 10.12173/j.issn.1005-0698.202312013

Reference: DAI Hengfen, ZHENG Caiyun, LIU Yunchun, ZHANG Hong, LIU Maobai,ZHANG Jinghua.Establishment and application of drug use evaluation criteria of argatroban[J].Yaowu Liuxingbingxue Zazhi,2024, 33(2):121-127.DOI: 10.12173/j.issn.1005-0698.202312013.[Article in Chinese]  Copied

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Abstract

Objective To establish the argatroban drug use evaluation (DUE) criteria and provide reference for the rational use of argatroban in clinical practice.

Methods Based on the domestic and foreign drug instructions of argatroban, referring to relevant guidelines and literature, the DUE standard rules were established by expert consultation. Using the established standard rules, the medical records of argatroban in the Fuzhou First Hospital Affiliated with Fujian Medical University from August 2020 to August 2022 were evaluated for the rationality of medication.

Results A total of 368 medical records were included, the rational rate of drug use was 48.64%, and the irrational drug use was mainly without indications (46.19%) and inappropriate combination of drugs (4.35%).

Conclusion The rational rate of argatroban clinical use in the hospital is not high, and the problems mainly include off-indication drug use and unreasonable combination drug use. Through the establishment and clinical application of DUE standard rules, the clinical use of argatroban can be further standardized and the ability of rational drug use can be improved.

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References

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