Objective  To observe the effect of Yanghe Tongmai pills combined with alprostadil on the curative effect and related indicators of diabetic lower extremity arteriosclerosis obliterans (DLASO).

Methods  A total of 140 patients with DLASO were randomly divided into the control group (70 cases) and the experimental group (70 cases). Both groups were given conventional symptomatic treatment. The control group was given alprostadil intravenous drip, and the experimental group was given Yanghe Tongmai pills on the basis of the control group. Before and after treatment, the TCM syndrome score, hemodynamics, hemorheology, microcirculation and other indicators of the two groups were measured, and the clinical efficacy and adverse reactions of the two groups were compared.

Results  After treatment, the scores of TCM syndromes, loop integral, flow pattern integral, loop circumference integral, plasma viscosity, whole blood low shear viscosity, whole blood high shear viscosity, serum LOX-1, CRP, TNF-α, IL-6 levels of patients in the two groups were significantly lower than before, while the blood flow of dorsalis pedis artery, ABI, TBI, and the diameter of the top loop vessels in the two groups were significantly higher than before (P<0.05); all indexes in the experimental group were significantly better than those in the control group (P<0.05). The total clinical effective rate of the experimental group (90.00%) was significantly higher than that of the control group (74.29%) (P<0.05), and there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).

Conclusion  The treatment of DLASO patients with Yanghe Tongmai pills combined with alprostadil can improve the curative effect, alleviate the clinical symptoms of patients, improve the blood microcirculation and hemorheology of lower limbs, reduce inflammatory reactions, and have fewer adverse reactions.

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