Objective  To observe the effects of knee intra-articular injection of sodium hyaluronate com-bined with compound betamethasone on the pain symptoms and knee function of patients with knee synovitis in plateau area.

Methods  A total of 118 patients with knee synovitis in plateau area were selected and divided into observation group (n=59) and control group (n=59) by random number table method. The control group was given knee intra-articular injection of 1mL compound betamethasone + 2mL 0.9% sodium chloride injec-tion, while the observation group was injected with 1mL compound betamethasone + 2mL sodium hyaluronate injection in the same way, and both groups were treated once a week for 4 weeks. Before treatment and on the 2nd week and the 4th week of treatment, the knee pain of patients was evaluated by Visual Analogue Scale (VAS), and the Lysholm score was used to determine the knee function, and the synovial thickness and joint cavity ef-fusion were measured. The clinical efficacy, as well as the levels of interleukin-1β (IL-1β), tumor necrosis fac-tor-α (TNF-α) and interleukin-6 (IL-6) in knee effusion before and after treatment were compared between the two groups of patients. Adverse drug reactions were observed in the two groups.

Results  The effective rate of observation group was 91.53%, which was significantly better than that in control group (P<0.05). On the 2nd week and 4th week after treatment, the knee VAS score, synovial thickness and joint cavity effusion volume in the two groups of patients were significantly decreased compared with those before treatment while the Lysholm score was significantly increased (P<0.01), and the above indicators were better in observation group than those in control group at the same time point (P<0.01). The levels of TNF-α, IL-1β and IL-6 in knee effusion after treatment were significantly reduced in both groups compared with those before treatment (P<0.01), and the above levels in observation group were significantly lower compared to control group (P<0.01). No obvious ad-verse drug reactions were observed in both groups during treatment.

Conclusion  Knee intra-articular injection of sodium hyaluronate combined with compound betamethasone can effectively relieve the pain symptoms of knee synovitis in plateau area, alleviate the joint inflammation, inhibit the synovial hypertrophy and promote the recovery of knee function with high safety.

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