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Home Articles Vol 34,2025 No.4 Detail

Analysis of one case of suspected leukemic reaction caused by inosine injection

Published on Apr. 27, 2025Total Views: 49 times Total Downloads: 9 times Download Mobile

Author: HUANG Yixin ZHU Qinwen WU Yifan LIU Xinyan

Affiliation: Department of Pharmacy, Suzhou Kowloon Hospital, Shanghai JiaoTong University School of Medicine, Suzhou 215028, Jiangsu Province, China

Keywords: Inosine injection Leukemic reaction Adverse drug reactions

DOI: 10.12173/j.issn.1005-0698.202405064

Reference: HUANG Yixin, ZHU Qinwen, WU Yifan, LIU Xinyan. Analysis of one case of suspected leukemic reaction caused by inosine injection[J]. Yaowu Liuxingbingxue Zazhi, 2025, 34(4): 480-484. DOI: 10.12173/j.issn.1005-0698.202405064.[Article in Chinese]

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Abstract

A 34-year-old female patient with multiple injuries in a car accident was admitted to hospital and received inosine injection. After 11 days, leukemioid reaction mainly characterized by "abnormal increase in white blood cell count" occurred, and the white blood cell count reached up to 38.26×109·L-1. Considering that inosine injection was the cause, the white blood cell count gradually decreased to 15.84×109·L-1 after the drug was stopped. Naranjo's assessment scale was used to evaluate the association of adverse reactions, with a score of 6, and the result was "very likely to be relevant". The cases reported in this paper belong to new adverse reactions caused by inosine injection, suggesting that inosine injection as an adjunct should pay attention to drug safety. If there is an abnormal increase in white blood cell count, it is necessary to be alert to the possibility of "leukemioid reaction" and stop the drug in time if necessary.

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References

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