Welcome to visit Zhongnan Medical Journal Press Series journal website!

Home Articles Vol 33,2024 No.4 Detail

One case of severe cardiac arrhythmias caused by Huoxiang Zhengqi liquid

Published on Apr. 29, 2024Total Views: 1609 times Total Downloads: 594 times Download Mobile

Author: ZHAO Yinping 1 XIN Xiaoyu 2 XIE Guibo 1 LI Huayan 1 YAN Yuan 1

Affiliation: 1. Department of Pharmacy, Nanfang Hospital Zengcheng Campus, Southern Medical University, Guangzhou 511300, China 2. Department of Cardiology, Nanfang Hospital Zengcheng Campus, Southern Medical University, Guangzhou 511300, China

Keywords: Huoxiang Zhengqi liquid Cardiac arhythmia Adverse drug reactions

DOI: 10.12173/j.issn.1005-0689.202311009

Reference: ZHAO Yinping, XIN Xiaoyu, XIE Guibo, LI Huayan, YAN Yuan.One case of severe cardiac arrhythmias caused by Huoxiang Zhengqi liquid[J].Yaowu Liuxingbingxue Zazhi,2024, 33(4):476-480.DOI: 10.19960/j.issn.1005-0698.202311009.[Article in Chinese]

  • Abstract
  • Full-text
  • References
Abstract

A 22-year-old male self-administered Huoxiang Zhengqi liquid (10 mL, bid) orally due to abdominal pain and diarrhea. The symptoms improved significantly on the same day. Palpitations occurred about 30 minutes after 10 mL Huoxiang Zhengqi Liuquid administration in the morning and afternoon of the next day and in the morning of the third day, respectively, which was spontaneously relieved. Electrocardiogram showed that multiple arrhythmias alternated, including disordered atrial rhythm, paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, frequent premature ventricular contractions, junctional premature contractions, atrioventricular block, and sinus bradycardia. After admission, the patient was given electrocardiography monitoring, polarizing fluid, verapamil injection, and other treatment methods to relieve symptoms, after 12 days of treatment, the patient's condition improved, and the electrocardiogram showed sinus rhythm. This case suggests that as an over-the-counter drug, the safety of Huoxiang Zhengqi liquid should be paid more attention by clinic and public. If patients manifest palpitation symptoms while using Huoxiang Zhengqi liquid, it is imperative to consider the potential for drug-induced serious arrhythmia and get medical treatment promptly.

Full-text
Please download the PDF version to read the full text: download
References

1.刘松松, 谢益明. 101例藿香正气水药品不良反应文献分析[J]. 中国药物警戒, 2017, 14(5): 317-320. [Liu SS, Xie YM. Literature analysis of 101 cases of adverse reactions induced by Huoxiang Zhengqi liquid[J]. Chinese Journal of Pharmacovigilance, 2017, 14(5): 317-320.] DOI: 10.3969/j.issn.1672-8629.2017.05.014.

2.Naranjo CA, Shear NH, Lanctôt KL. Advances in the diagnosis of adverse drug reactions[J]. J Clin Pharmacol, 1992, 32(10): 897-904. DOI: 10.1002/j.1552-4604.1992.tb04635.x.

3.中国药典2020年版. 一部[S]. 2020: 1881, 263, 123-124.

4.李田倪. 藿香正气水(滴丸、胶囊、颗粒)致不良反应108例分析[C]. //中国药学会医院药学专业委员会. 第二十三届全国儿科药学学术会议论文集, 2012: 1.

5.李家奇, 薛珍珍, 杨滨. 不同产地和树龄厚朴样本姜炙前后化学成分的定性定量分析[J]. 中国中药杂志, 2023, 48(9): 2435-2454. [Li JQ, Xue ZZ, Yang B. Chemical components of Magnoliae Officinalis Cortex of different origins and with different tree ages before and after being processed with ginger juice:a qualitative and quantitative analysis[J]. China Journal of Chinese Materia Medica, 2023, 48(9): 2435-2454.] DOI: 10.19540/j.cnki.cjcmm.20230208.301.

6.郭敬, 陈弘东, 徐立鹏, 等. 厚朴临床用量研究[J]. 山东中医杂志, 2015, 34(12): 950-952. [Guo J, Chen HD, Xu LP, et al. Study on the clinical dosage of Mangnolia officinalis[J]. Shandong Journal of Traditional Chinese Medicine, 2015, 34(12): 950-952.] DOI: 10.16295/j.cnki.0257-358x.2015.12.022.

7.周津通, 郑余林, 刘江南. 藿香正气水致室上性心动过速4例[J]. 江西中医药, 1992(1): 41. [Zhou JT, Zheng YL, Liu JN. Four cases report of superventricular tachycardia caused by Huoxiang Zhengqi liquid[J]. Jiangxi Journal of Traditional Chinese Medicine, 1992(1): 41.] https://www.cnki.com.cn/Article/CJFDTotal-JXZY199201039.htm.

8.张权, 荆文光, 程显隆, 等. 基于9种成分测定的厚朴炮制过程质量传递规律研究[J]. 中草药, 2020, 51(3): 647-652. [Zhang Q, Jing WG, Cheng XL, et al. Study on quality transfer law of Magnoliae officinalis cortex in processing based on nine components determination[J]. Chinese Traditional and Herbal Drugs, 2020, 51(3): 647-652.] DOI: 10.7501/j.issn.0253-2670.2019.03.014.

9.袁金凤, 乔艺涵, 彭诗涛, 等. 厚朴及其不同炮制品中挥发性成分GC-MS分析[J]. 中成药, 2019, 41(6): 1354-1357. [Yuan JF, Qiao YH, Peng ST, et al. Analysis on volatile constituents in Magnolia officinals and different processed products by GC-MS[J]. Chinese Traditional Patent Medicine, 2019, 41(6): 1354-1357.] DOI: 10.3969/j.issn.1001-1528.2019.06.031.

10.黄凤英, 高健美, 龚其海. 半夏药理作用及其毒性研究进展[J]. 天然产物研究与开发, 2020, 32(10): 1773-1781. [Huang FY, Gao JM, Gong QH. Research progress on pharmacological effects and toxicity of Pinellia ternata[J]. Natural Product Research and Development, 2020, 32(10): 1773-1781.] DOI: 10.16333/j.1001-6880.2020.10.020.

11.吕悦. 半夏不同炮制品中潜在毒性成分差异与其刺激性、肝毒性相关性研究[D]. 哈尔滨: 东北林业大学, 2023.

12.谷世平. 生半夏中毒6例抢救体会[J]. 河北中医, 2006, 28(4): 271-272. [Gu SP. Emergency treatment of unprocessed Pinellia ternata poisoning: an analysis of 6 cases[J]. Hebei Journal of Traditional Chinese Medicine,2006, 28(4): 271-272.] DOI: 10.3969/j.issn.1002-2619.2006.04.025.

13.赵亚良, 李永胜. 中药生半夏中毒2例救治体会[J]. 西北国防医学杂志, 2009, 30(6): 447. [Zhao YL, Li YS. Experience in the treatment of unprocessed Pinellia ternata poisoning: an analysis of 2 cases[J]. Medical Journal of National Defending Forces in Northwest China, 2009, 30(6): 447.] DOI: 10.16021/j.cnki.1007-8622.2009.06.027.

Popular papers
Last 6 months