A case of severe anemia induced by ensartinib, anlotinib, pemetrexed and zoledronic acid

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Author: Ting-Ting ZHENG ¹ Xiao-Fang WANG ² Yu XU ² Wei ZHANG ¹  Jian-Cun ZHEN ¹

Affiliation: 1. Department of Pharmacy, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China 2. Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China

Keywords: Ensartinib Anlotinib Pemetrexed Zoledronic acid Severe anemia Adverse drug reactions

DOI: 10.19960/j.issn.1005-0698.202309014

Reference: Ting-Ting ZHENG, Xiao-Fang WANG, Yu XU, Wei ZHANG, Jian-Cun ZHEN.A case of severe anemia induced by ensartinib, anlotinib, pemetrexed and zoledronic acid[J].Yaowu Liuxingbingxue Zazhi,2023, 32(9):1071-1075.DOI: 10.19960/j.issn.1005-0698.202309014.[Article in Chinese]  Copied

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Abstract

A 42-year-old male patient with stage IV right lung adenocarcinoma was diagnosed for 9 years, and he was treated with multiple chemotherapy and targeted drugs. Due to disease progression, the targeted therapy was adjusted to ensartinib hydrochloride capsules combined with anlotinib, pemetrexed disodium and zoledronic acid. After 82 days of continuous administration of ensartinib, the patient had sudden fatigue without obvious inducement, and the hemoglobin decreased from 132 g·L^-1 before the administration of ensartinib to 59 g·L^-1. The patient was diagnosed as severe anemia, which was considered to be related to ensartinib, anlotinib, pemetrexed and zoledronic acid, and the association of adverse reactions was evaluated as "possible". After drug withdrawal and symptomatic support treatment, the hemoglobin recovered to 97 g·L^-1 on the 6th day of admission. Ensartinib has been approved for marketing in China for a short time, and there are few reports of severe anemia. Reminder of this case, key attention should be paid to some drugs with limited use experience in clinical treatment, in order to find some adverse reactions with low incidence.

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References

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