Effect of cod liver oil ointment combined with desonide cream on allergic contact dermatitis in children and skin barrier repair

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Author: Ying ZENG Chun-Fang GAO  Gui-Li FU Huan KE Qian YANG

Affiliation: Department of Dermatology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan 430019, China

Keywords: Allergic contact dermatitis Cod liver oil ointment Desonide cream Skin barrier

DOI: 10.19960/j.issn.1005-0698.202308003

Reference: Ying ZENG, Chun-Fang GAO, Gui-Li FU, Huan KE, Qian YANG.Effect of cod liver oil ointment combined with desonide cream on allergic contact dermatitis in children and skin barrier repair[J].Yaowu Liuxingbingxue Zazhi,2023, 32(8): 856-861.DOI: 10.19960/j.issn.1005-0698.202308003.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To explore the effect of cod liver oil ointment combined with desonide cream in the treatment of allergic contact dermatitis (ACD) in children and the repair effect of skin barrier.

Methods 80 children with ACD were selected, and were randomly divided into control group and experimental group, with 40 children in each group. The control group were treated with desonide cream, and the experimental group were treated with cod liver oil ointment combined with desonide cream. After 2 weeks of the treatment, the changes in subjective and objective symptom scores and index of skin barrier[cuticle water content, epidermal oil content and through epidermal water loss(TEWL)] before and after treatment were compared in control group and experimental group. The total effective rates were compared between the two groups. Spearman method was used to analyze the correlation among the clinical efficacy of the experimental group and the cuticle water content, epidermal oil content, and TEWL.

Results After treatment, the scores of local pruritus, burning sensation, erythema, papule, blister, skin lesion area and other symptoms in control group and experimental group were decreased in varying degrees (P<0.01), and the above scores in experimental group were lower than those in control group (P<0.05). After treatment, the epidermal oil content and cuticle water content in control group and experimental group were increased in varying degrees (P<0.05), and TEWL were decreased (P<0.01). The epidermal oil content and cuticle water content in experimental group were higher than those in control group, and TEWL was lower than that in control group (P<0.05). After treatment, the clinical efficacy of experimental group was higher than that of control group (92.50% vs. 75.00%, P<0.05). The total effective rate of the experimental group after treatment was positively correlated with the content of epidermal oil and water in the stratum corneum (r_s=0.496, 0.438, P<0.05), and negatively correlated with the level of TEWL (r_s=-0.483, P<0.05).

Conclusion Cod liver oil ointment combined with desonide cream than Desonide cream can effectively relieve the symptoms of local focus in the clinical treatment of children’s ACD, and repair the damaged skin barrier, which is superior to the treatment with desonide cream alone.

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