Effect of cod liver oil ointment combined with desonide cream on allergic contact dermatitis in children and skin barrier repair

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Author: Ying ZENG Chun-Fang GAO  Gui-Li FU Huan KE Qian YANG

Affiliation: Department of Dermatology, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Huazhong University of Science & Technology, Wuhan 430019, China

Keywords: Allergic contact dermatitis Cod liver oil ointment Desonide cream Skin barrier

DOI: 10.19960/j.issn.1005-0698.202308003

Reference: Ying ZENG, Chun-Fang GAO, Gui-Li FU, Huan KE, Qian YANG.Effect of cod liver oil ointment combined with desonide cream on allergic contact dermatitis in children and skin barrier repair[J].Yaowu Liuxingbingxue Zazhi,2023, 32(8): 856-861.DOI: 10.19960/j.issn.1005-0698.202308003.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To explore the effect of cod liver oil ointment combined with desonide cream in the treatment of allergic contact dermatitis (ACD) in children and the repair effect of skin barrier.

Methods 80 children with ACD were selected, and were randomly divided into control group and experimental group, with 40 children in each group. The control group were treated with desonide cream, and the experimental group were treated with cod liver oil ointment combined with desonide cream. After 2 weeks of the treatment, the changes in subjective and objective symptom scores and index of skin barrier[cuticle water content, epidermal oil content and through epidermal water loss(TEWL)] before and after treatment were compared in control group and experimental group. The total effective rates were compared between the two groups. Spearman method was used to analyze the correlation among the clinical efficacy of the experimental group and the cuticle water content, epidermal oil content, and TEWL.

Results After treatment, the scores of local pruritus, burning sensation, erythema, papule, blister, skin lesion area and other symptoms in control group and experimental group were decreased in varying degrees (P<0.01), and the above scores in experimental group were lower than those in control group (P<0.05). After treatment, the epidermal oil content and cuticle water content in control group and experimental group were increased in varying degrees (P<0.05), and TEWL were decreased (P<0.01). The epidermal oil content and cuticle water content in experimental group were higher than those in control group, and TEWL was lower than that in control group (P<0.05). After treatment, the clinical efficacy of experimental group was higher than that of control group (92.50% vs. 75.00%, P<0.05). The total effective rate of the experimental group after treatment was positively correlated with the content of epidermal oil and water in the stratum corneum (r_s=0.496, 0.438, P<0.05), and negatively correlated with the level of TEWL (r_s=-0.483, P<0.05).

Conclusion Cod liver oil ointment combined with desonide cream than Desonide cream can effectively relieve the symptoms of local focus in the clinical treatment of children’s ACD, and repair the damaged skin barrier, which is superior to the treatment with desonide cream alone.

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1.慕彰磊, 张建中. 皮肤屏障与特应性皮炎[J]. 临床皮肤科杂志, 2019, 48(11): 707-709. [Mu ZL, Zhang JZ. Skin barrier and atopic dermatitis[J]. Journal of Clinical Dermatology, 2019, 48(11): 707-709.] DOI: 10.16761/j.cnki.1000-4963.2019.11.021.

2.中华中医药学会皮肤科分会. 面部激素药毒(糖皮质激素依赖性皮炎)中医治疗专家共识[J]. 中国中西医结合皮肤性病学杂志, 2019, 18(5): 497-499. DOI: 10.3969/j.issn.1672-0709.2019.05.039.

3.郑旭, 高建明, 黄静. 他克莫司联合地奈德乳膏对化妆品接触性皮炎的效果评价及对血清IgE、TGF-β及IL-10水平的影响[J]. 中国美容医学, 2021, 30(6): 68-71. [Zheng X, Gao JM, Huang J. Evaluation of the effect of tacrolimus combined with deneride cream on cosmetic dermatitis and its effect on serum IgE, TGF-β and IL-10 levels[J]. Chinese Journal of Aesthetic Medicine, 2021, 30(6): 68-71.] DOI: 10.15909/j.cnki.cn61-1347/r.004459.

4.曾颖, 付桂莉, 郑源泉, 等. 保湿剂在变态反应性接触性皮炎治疗中的应用及其对免疫因子的影响[J]. 中国免疫学杂志, 2021, 37(11): 1371-1375. [Zeng Y, Fu GL, Zheng YQ, et al. Application of humectant in treatment of allergic contact dermatitis and its effect on immune factors[J]. Chinese Journal of Immunology, 2021, 37(11): 1371-1375.] DOI: 10.3969/j.issn.1000-484X.2021. 11.017.

5.马琳, 主编. 儿童皮肤病学[M]. 北京: 人民卫生出版社, 2014: 4-6.

6.赵辨, 主编. 中国临床皮肤病学, 第3版 [M]. 南京: 江苏科学技术出版社, 2010: 605-706.

7.栾梅, 李利. 皮肤屏障功能的无创检测技术[J]. 中国医学文摘（皮肤科学）, 2017, 34(4): 443-446. [Luan M, Li L. Noninvasive technology of skin barrier[J]. China Medical Abstracts (Dermatology), 2017, 34(4): 443-446.] DOI: CNKI:SUN:ZYXW.0.2017-04-016.

8.路坦, 申春平, 田晶. 保湿润肤剂在儿童中重度特应性皮炎治疗中的辅助作用[J]. 中国皮肤性病学杂志, 2019, 33(7): 757-760. [Lu T, Shen CP, Tian J. Auxiliary effects of emollient in children with moderate to severe atopic dermatitis[J]. Chinese Journal of Dermatovenereology, 2019, 33(7): 757-760.] DOI: 10.13735/j.cjdv.1001-7089.201901132.

9.Byrd AL, Belkaid Y, Segre JA. The human skin microbiome[J]. Nat Rev Microbiol, 2018, 16(3): 143-155. DOI: 10.1038/nrmicro.2017.157.

10.Yosipovitch G, Misery L, Proksch E, et al. Skin barrier damage and itch: review ofmechanisms, topical management and future directions[J]. Acta Derm Venereol, 2019, 99(13): 1201-1209. DOI: 10.2340/00015555-3296.

11.吴志华, 主编. 皮肤科治疗学[M]. 北京: 科学出版社, 2006: 443-445.

12.张焕梅, 赵俊萍, 林妙青, 等. 地奈德乳膏联合复方多粘菌素B软膏治疗儿童中重度特应性皮炎疗效分析[J]. 皮肤病与性病, 2020, 42(4): 82-84. [Zhang HM, Zhao JP, Lin MQ, et al. Analysis of the efficacy of desnide cream combined with compound polymyxin B ointment in the treatment of moderate and severe atopic dermatitis in children[J]. Dermatology and Venereology, 2020, 42(4): 82-84.] DOI: 10.3969/j.issn.1002-1310.2020.01.048.

13.刘存军. 地奈德乳膏联合复方多粘菌素B软膏在儿童中重度特应性皮炎中的应用价值[J]. 医学美学美容, 2020, 29(13): 55. [Liu CJ. Application value of desnide cream combined with compound polymyxin B ointment in children with moderate and severe atopic dermatitis[J]. Journal of Medical Aesthetice and Cosmetology, 2020, 29(13): 55.] https://kns.cnki.net/kcms/detail/detail.aspx?FileName=KMYX202012021&DbName=CJFQ2020.

14.Vaughn AR, Clark AK, Sivamani RK, et al. Natural oils for skin-barrier repair: ancient compounds now backed by modern science[J]. Am J Clin Dermatol, 2018, 19(1): 103-117. DOI: 10.1007/s40257-017-0301-1.

15.王孝盼, 权晟, 陈利红, 等. 富含亚油酸-神经酰胺的保湿剂在特应性皮炎鼠模型中的作用研究[J]. 中国麻风皮肤病杂志, 2019, 35(11): 647-650. [Wang XP, Quan S, Chen LH, et al. Effects of linoleic acid-ceramide-containing moisturizer on atopic dermatitis mouse model[J]. China Journal of Leprosy and Skin Diseases, 2019, 35(11): 647-650.] DOI: CNKI:SUN:MALA.0.2019-11-003.

16.邹祖鹏, 朱磊. 保湿剂的临床应用实践[J]. 中国临床医师杂志, 2020, 48(4): 398-401. [Zou ZP, Zhu L. Clinical application of humectant[J]. Chinese Journal of Clinicians, 2020, 48(4): 398-401.] DOI: 10.3969/j.issn.2095-8552. 2020.04.007.

17.Wang Y, Viennet C, Jeudy A, et al. Assessment of the efficacy of a new complex antisensitive skin cream[J]. J Cosmet Dermatol, 2018, 17(6): 1101-1107. DOI: 10.1111/jocd.12486.

18.方天雯, 涂颖, 李丹晨, 等. 药物联合含青刺果及马齿苋保湿霜和防晒乳治疗慢性光化性皮炎的临床研究[J]. 中华医学美学美容杂志, 2020, 26(2): 93-97. [Fang TW, Tu Y, Li DC, et al. Clinical treatment of chronic actinic dermatitis with the drugs combined Prinsepia utilis oil and purslane moisturizer and sunscreen cream[J]. Chinese Journal of Medical Aesthetics and Cosmetology, 2020, 26(2): 93-97.] DOI: 10.3760/cma.j.issn.1671-0290. 2020.02.004.