This article reported the process of individualized medication management by a clinical pharmacist in the treatment of a patient with autoimmune pancreatitis (AIP) complicated by a relapse of ulcerative colitis (UC). Upon admission, in collaboration with the clinical pharmacist, the physician formulated a combined treatment plan of oral prednisone and mesalazine based on the patient's condition and the latest research literature. After 3 days of medication, the patient's diarrhea symptoms worsened, and colonoscopy revealed a severe, extensive flare of UC. After discussing, the physician and clinical pharmacist decided to switch the oral prednisone to intravenous methylprednisolone sodium succinate and replace mesalazine suppositories with mesalazine enema. Subsequently, the patient developed a fever and was diagnosed with Clostridiodes difficile infection. After a comprehensive evaluation, the clinical pharmacist recommended the use of metronidazole and implemented careful pharmaceutical monitoring. After 5 days of treatment, the patient's symptoms significantly improved without any adverse reactions. This case highlights the critical role of clinical pharmacists in managing complex clinical situations, particularly in optimizing treatment regimens and ensuring medication safety. It also provides practical experience and guidance for physicians and clinical pharmacists in handling similar cases.

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