Objective  By collecting the instructions of commonly used clinical sulfonamides non-antibacterial drugs, the labeling of cross-allergic items in the instructions of such drugs was analyzed, and the appropriate prescription review strategy was explored.Methods  In December 2021, by querying Yaozhi.com's instruction manual database, medication assistant software (mobile version) and MCDEX software (online version), we collected the instructions for non-antibacterial drugs with sulfonamide structure commonly used in China, and the instructions for cross-allergic warnings and Taboo content was summarized and analyzed by Excel.

Results  There were 17 drugs in 5 categories and 641 non-antibacterial drug instructions with sul-fonamide structure, including 115 circulating diuretics, 189 thiazides and related diuretics, and 273 sulfonylurea antibacterial drugs, 6 carbonic anhydrase inhibitors. Among them, the instructions of 8 drugs differed on the labeling of cross allergy.

Conclusion  At present domestic sulfanilamide structure of antimicrobial manual al-lergic to cross item tagging is larger differences, which reflects the cross of the drug allergy still exists in the practical application of the larger controversy. In the process of formulating the auditor's strategy, the differ-ences in the explanation should be well controlled, according to the description of the corresponding instruc-tions, we can accurately identify and remind the cross allergy of such drugs.

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