Myocardial injury induced by oxitinib in a patient with advanced lung adenocarcinoma

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Author: Guo-Yin LI ¹ 2 Shu-Yuan LIN ² Li BIAN ²  Ying SUN ¹

Affiliation: 1. Department of Pharmacy, Lianyungang First People’s Hospital (the First Affiliated Hospital of Kangda College of Nanjing Medical University) , Lianyungang 222000, Jiangsu Province, China 2. Pharmacy of Lianyungang Xuwei New District People’s Hospital, Lianyungang 222000, Jiangsu Province, China

Keywords: Oshtinib Myocardial injury Adverse drug reactions case report

DOI: 10.19960/j.issn.1005-0698.202302015

Reference: Guo-Yin LI, Shu-Yuan LIN, Li BIAN, Ying SUN.Myocardial injury induced by oxitinib in a patient with advanced lung adenocarcinoma[J].Yaowu Liuxingbingxue Zazhi,2023, 32(2): 233-237.DOI: 10.19960/j.issn.1005-0698.202302015.[Article in Chinese]  Copied

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Abstract

A 70-year-old male patient with stage IV left lower lung adenocarcinoma was treated with gefitinib. After taking it for 3 months, the patient developed drug resistance and was treated with oxitinib instead. After 5 months of continuous administration of oxitinib, the patient suffered from sudden dyspnea, orthostatic breathing with sweating, and edema of both lower limbs. The ECG showed ST-T changes, hsTnI 11 025.5 pg · mL^-1, CK 798 U · L^-1, CK-MB 3.1 ng · mL^-1, NT-proBNP 3 191 pg · mL^-1, and LVEF decreased from 58% to 30%, with a decrease of more than 10% from the baseline and lower than the lower limit of the normal value. It was considered as acute myocardial infarction and heart failure. The adverse reaction correlation score was 6 points by using the Roche Adverse Drug Re-action Assessment Scale. It was evaluated by Naranjo’s score scale that the adverse reaction of myocardial injury was “likely” caused by oxitinib. Myocardial injury improved after drug withdrawal and symptomatic support treatment.

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