Rationality evaluation of alteplase in the treatment of acute ischemic stroke based on weighted TOPSIS method

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Author: GUO Sitong ¹ CAI Huiya ² SU Henghai ¹  ZHANG Jinhua ³

Affiliation: 1. Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530000, China 2. Department of Pharmacy, The Second Hospital of Zhangzhou, Zhangzhou 363199, Fujian Province, China 3. Department of Pharmacy, Fujian Maternity and Child Health Care Hospital, Fuzhou 350001, China

Keywords: Alteplase Acute ischemic stroke Drug use evaluation Weighted TOPSIS method Rational drug use

DOI: 10.12173/j.issn.1005-0698.202312044

Reference: GUO Sitong, CAI Huiya, SU Henghai, ZHANG Jinhua.Rationality evaluation of alteplase in the treatment of acute ischemic stroke based on weighted TOPSIS method[J].Yaowu Liuxingbingxue Zazhi,2024, 33(6):642-651.DOI: 10.12173/j.issn.1005-0698.202312044.[Article in Chinese]  Copied

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Abstract

Objective To establish a drug use evaluation (DUE) criteria for alteplase in the treatment of acute ischemic stroke (AIS), and to evaluate the use of the drug by weighted TOPSIS method, to provide a reference for rational use of alteplase.

Methods Based on the drug package insert, relevant guidelines, the DUE criteria for alteplase in the treatment of AIS were developed combined with expert consultation. The weighted TOPSIS method was used to evaluate the rationality of alteplase use in inpatients with AIS in the People's Hospital of Guangxi Zhuang Autonomous Region from January 2020 to June 2022, based on the attribute hierarchy model.

Results A total of 126 medical records were included. Among them, 80 cases (63.49%) exhibited a high degree of adherence (C_i > 0.8) between the prescribed drug regimens and the optimal recommendations, which was considered reasonable. Additionally, 40 cases (31.75%) fell within the range of 0.6 ≤ C_i ≤ 0.8, indicating a basic reasonable adherence, and 6 cases (4.76%) had a C_i < 0.6, suggesting an unreasonable level of adherence. The irrational use of the drug mainly involved contraindications (32.54%), dosage (7.14%), and drug conversion (7.14%), among other aspects.

Conclusion The weighted TOPSIS method is used to evaluate the rationality of alteplase in the treatment of acute ischemic stroke (AIS), and the results are intuitive and comprehensive. There are still problems in the use of alteplase in this hospital, and it is necessary to strengthen intervention to promote rational clinical use of alteplase in terms of contraindication of medication and dosage, etc.

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