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Home Articles Vol 33,2024 No.5 Detail

A case of autoimmune hemolytic anemia caused by thalidomide

Published on May. 07, 2024Total Views: 1454 times Total Downloads: 728 times Download Mobile

Author: CHEN Xiaoyan 1 KONG Wenqiang 1 YANG Kun 2

Affiliation: 1. Department of Pharmacy, Zigong First People’s Hospital, Zigong 643000, Sichuan Province,China 2. Department of Hematology, Zigong First People’s Hospital, Zigong 643000, Sichuan Province,China

Keywords: Thalidomide Autoimmune hemolytic anemia Thalassemia

DOI: 10.12173/j.issn.1005-0698.202309109

Reference: CHEN Xiaoyan, KONG Wenqiang, YANG Kun.A case of autoimmune hemolytic anemia caused by thalidomide[J].Yaowu Liuxingbingxue Zazhi,2024, 33(5):591-594.DOI: 10.19960/j.issn.1005-0698.202309109.[Article in Chinese]

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Abstract

This paper reported a 15-year-old girl with β-thalassemia major became dependent on blood transfusions from 6 months after birth whose blood transfusion needs increased with age. The girl started treatment with thalidomide at the age of 15. She became transfusion independent one month after starting thalidomide treatment, and her hemoglobin levels were maintained at 98-109 g·L-1. However, the girl subsequently developed symptoms of dizziness and fatigue in the 11th month of thalidomide treatment. Her hemoglobin was decreased and indirect antiglobulin test and direct antiglobulin test were positive. She was diagnosed with new onset autoimmune hemolytic anemia, which was considered to be related to thalidomide, and the association of adverse reactions was evaluated as "possible". Indirect antiglobulin test and direct antiglobulin test were negative after drug withdrawal and glucocorticoid therapy. Therefore, patients with thalassemia who are treated with thalidomide should be carefully monitored for the development of autoimmune hemolytic anemia.

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