Objective  To observe the clinical effect of remimazolam in painless gastroscopy of elderly patients at high altitude.

Methods  A total of 192 elderly patients who underwent painless gastroscopy were divided into obser-vation group and control group by random number table method with 96 cases in each group. The control group re-ceived propofol intervention, and the observation group received remimazolam intervention. Respiratory rate at dif-ferent time points, stress response indicators before and after anesthesia, recovery time, and the incidence of adverse drug reactions were compared between groups.

Results The respiratory rates of observation group before the insertion of gastroscope and at the end of gastroscopy were lower than those of the control group (P<0.05). The levels of blood glucose, epinephrine and cortisol in observation group at the insertion of gastroscope were significantly higher than those before anesthesia, while were lower than those in the control group at insertion (P<0.05). The recovery time was shorter than that of the control group (P<0.05), and the incidence of adverse reactions was lower than that in the con-trol group (P<0.05).

Conclusion  Remimazolam is clinically effective in painless gastroscopy of elderly patients at high altitude.

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