Oral lichenoid drug reactions induced by secukinumab injection: a case report

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Author: LI Dandan ¹ WAN Zixin ²  WANG Jianli ¹

Affiliation: 1. Department of Pharmacy, State Key Laboratory of Oral Diseases/National Center for Stomatology/National Clinical Research Center for Oral Diseases/West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China 2. Department of Oral Pathology, State Key Laboratory of Oral Diseases/National Center for Stomatology/National Clinical Research Center for Oral Diseases/West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Keywords: Secukinumab Oral lichenoid drug reactions Adverse drug reactions

DOI: 10.12173/j.issn.1005-0698.202311027

Reference: LI Dandan, WAN Zixin, WANG Jianli.Oral lichenoid drug reactions induced by secukinumab injection: a case report[J].Yaowu Liuxingbingxue Zazhi,2024, 33(4):461-465.DOI: 10.12173/j.issn.1005-0698.202311027.[Article in Chinese]  Copied

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Abstract

A 57-year-old female patient was treated with secukinumab injection for psoriasis. After the eighth administration, large area of reticular streaks with hyperemia and erosion appeared on the dorsum of the tongue and left buccal mucosa, which improved after three weeks of corticosteroids treatment. The symptoms worsened after re-administration and a diagnosis of an oral lichenoid drug reaction (OLDR) was made, which improved after eight weeks of corticosteroids treatment. There was no recurrence four months after secukinumab injection withdrawal. By correlation analysis, the causal relationship between OLDR and Secukinumab injection was evaluated as "be sure", which had not been reported in China. The clinical manifestations of oral lichenoid drug reactions were unilateral buccal mucosa with hyperemia and erosion. Discontinuation of suspected drugs and topical application of corticosteroids were the most effective treatments.

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