Drug use evaluation of tranexamic acid and sodium chloride injection based on weighted TOPSIS method

Published on Dec. 29, 2023Total Views: 1422 times Total Downloads: 511 times Download Mobile

Author: Mei-Juan LI ¹ Xiu-Mei LIU ² Lei LI ³ Jian-Ping LIU ¹ Li-Qin LIU ¹ Qian XIANG ⁴  Jin-Hua ZHANG ⁵  Qing LI ¹

Affiliation: 1. Department of Pharmacy, First Hospital of Shanxi Medical University, Taiyuan 030001, China 2. Department of Pharmacy, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou 450003, China 3. Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan 030001, China 4. Department of Pharmacy, Peking University First Hospital, Beijing 100034, China 5. Department of Pharmacy, Fujian Maternity and Child Health Care Hospital, Fuzhou 350001, China

Keywords: Tranexamic acid and sodium chloride injection Weighted TOPSIS method Drug use evaluation

DOI: 10.19960/j.issn.1005-0698.202312001

Reference: Mei-Juan LI, Xiu-Mei LIU, Lei LI, Jian-Ping LIU, Li-Qin LIU, Qian XIANG,Jin-Hua ZHANG, Qing LI.Drug use evaluation of tranexamic acid and sodium chloride injection based on weighted TOPSIS method[J].Yaowu Liuxingbingxue Zazhi,2023, 32(12): 1321-1330.DOI: 10.19960/j.issn.1005-0698.202312001.[Article in Chinese]  Copied

Abstract
Full-text
References

Abstract

Objective To establish the rules of drug use evaluation (DUE) of tranexamic acid and sodium chloride injection, and to provide a basis for clinical rational drug use.

Methods Based on the drug instruction and referring to relevant guidelines and literature, the DUE criteria were established, and the weighted TOPSIS method was used to evaluate the rationality of medical records discharged from the First Hospital of Shanxi Medical University from February to August 2022.

Results Among the 171 cases of medication regimen, there are were 66 cases (38.60%) close to the optimal regimen (C_i ≥0.8) (reasonable); C_i was between 0.6 and 0.8 (basically reasonable) in 73 cases (42.69%); and C_i <0.6 (unreasonable) in 32 cases (18.71%). The unreasonable phenomenon mainly appeared in adverse reaction monitoring, medication administered, indications and so on.

Conclusion The weighted TOPSIS method is used to evaluate the rationality of tranexamic acid and sodium chloride injection, and its evaluation results are more intuitive and convenient.

Full-text

Please download the PDF version to read the full text: download

References

1.刘晓玲, 邢亚兵, 裴保方, 等. 某儿童医院围手术期止血药物预防性用药情况分析[J]. 中国合理用药探索, 2023, 20(3): 73-77. [Liu XL, Xing YB, Pei BF, et al. Analysis on the prophylactic use of hemostatic drugs during perioperative period in a Children's hospital[J]. Chinese Journal of Rational Drug Use, 2023, 20(3): 73-77.] DOI: 10.3969/j.issn.2096-3327.2023.03.011.

2.Cesarman-Maus G, Hajjar KA. Molecular mechanisms of fibrinolysis[J]. Br J Haematol, 2005, 129(3): 307-321. DOI: 10.1111/j.1365-2141.2005.05444.x.

3.周骅, 王增. 浙江11家医院2012—2017年度肺癌患者止血药应用分析[J]. 中国乡村医药, 2020, 27(6): 38-39, 73. [Zhou H, Wang Z. The analysis of hemostatic drug application in lung cancer patients from 2012-2017 in 11 hospitals in Zhejiang[J]. Chinese Journal of Rural Medicine and Pharmacy, 2020, 27(6): 38-39, 73.] DOI: 10.3969/j.issn.1006-5180.2020.06.021.

4.程莉玲, 曹健. 加权TOPSIS法在医院综合评价中的应用[J]. 中国医院统计, 2006, 13(1): 17-19. [Cheng LL, Cao J. Application of weighted TOPSIS in comprehensive evaluation of hospital[J]. Chinese Journal of Hospital Statistics, 2006, 13(1): 17-19.] DOI: 10.3969/j.issn. 1006-5253. 2006.01.006.

5.刘继斌, 曲成毅, 王瑞花. 基于属性AHM的Topsis综合评价及其应用[J]. 现代预防医学, 2006, 33(10): 1862-1863. [Liu JW, Qu CY, Wang RH. The comprehensive evaluation of Topsis based on attribute AHM and its application[J]. Modern Preventive Medicine, 2006, 33(10): 1862-1863.] DOI: 10.3969/j.issn.1003- 8507.2006.10.049.

6.中华医学会血液学分会血栓与止血学组. 血管性血友病诊断与治疗中国指南（2022年版）[J]. 中华血液学杂志, 2022, 43(1): 1-6. DOI: 10.3760/cma.j.issn.0253- 2727.2022.01.001.

7.文爱清, 张连阳, 蒋东坡, 等. 严重创伤输血专家共识[J]. 中华创伤杂志, 2013, 29(8): 706-710. [Wen AQ, Zhang LY, Jiang DP, et al. Expert consensus on blood transfusion for severe trauma[J]. Chinese Journal of Trauma, 2013, 29(8): 706-710.] DOI: 10.3760/cma.j.issn.1001-8050.2013.08. 011.

8.杨宝学, 张兰, 主编. 实用临床药物学 [M]. 北京: 中国医药科技出版社, 2018: 446-447.

9.董漪, 郭珍妮, 李琦, 等. 中国脑血管病临床管理指南(节选版)——蛛网膜下腔出血临床管理[J]. 中国卒中杂志, 2019, 14(8): 814-818. [Dong Y, Guo ZN, Li Q, et al. Chinese clinical management guidelines for cerebrovascular disease (abridged version) - Clinical management of subarachnoid hemorrhage[J]. Chinese Journal of Stroke, 2019, 14(8): 814-818.] DOI: 10.3969/ j.issn.1673-5765.2019.08.015.

10.王学锋, 蔡晓红. 出血性疾病治疗应用血液制剂的专家共识[J]. 中国输血杂志, 2017, 30(7): 661-663. [Wang XF, Cai XH. Expert consensus on the application of blood preparations for the treatment of hemorrhagic diseases[J]. Chinese Journal of Blood Transfusion, 2017, 30(7): 661-663.] DOI: 10.13303/j.cjbt.issn.1004-549x.2017.07.001.

11.串俊兰, 吕晶, 韩勇. 氨甲环酸致不良反应个例报道文献分析[J]. 中国药师, 2013, 16(3): 456-458. [Chuan JL, Lyu J, Han Y. Analysis of literature on individual case reports of adverse reactions caused by tranexamic acid[J]. China Pharmacist, 2013, 16(3): 456-458.] DOI: 10.3969/j.issn.1008-049X.2013.03.056.

12.中华医学会外科学分会. 中国普通外科围手术期血栓预防与管理指南[J]. 消化肿瘤杂志(电子版), 2016, 8(2): 57-62. DOI: 10.3969/j.issn.1674-7402.2016.02.004.

13.高永, 王玖, 石德文. 加权TOPSIS法综合评价在Excel中的实现[J]. 中国卫生统计, 2007, 24(4): 428-429. [Gao Y, Wang J, Shi DW. The implementation of weighted TOPSIS method for comprehensive evaluation in Excel[J]. Chinese Journal of Health Statistics, 2007, 24(4): 428-429.] DOI: 10.3969/j.issn.1002-3674.2007.04.035.

14.孙博, 刘勋, 张二锋, 等. 基于加权TOPSIS法的亚胺培南西司他丁药物利用评价[J]. 药物流行病学杂志, 2021, 30(12): 827-832. [Sun B, Liu X, Zhang EF, et al. Evaluation of drug use evaluation of imipenem and cilastatin based on weighted TOPSIS method[J]. Chinese Journal of Pharmacoepidemiology, 2021, 30(12): 827-832.] DOI: 10.19960/j.cnki.issn1005-0698.2021. 12.008.

15.Srivastava A, Santagostino E, Dougall A, et al. WFH Guidelines for the Management of Hemophilia, 3rd edition[J]. Haemophilia, 2020, 26(Suppl 6): 1-158. DOI: 10.1111/hae.14046.

16.Wijetilleka S, Yeo D, Sharma B. Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid[J]. BMJ Case Rep, 2017, 2017: bcr2016218246. DOI: 10.1136/bcr-2016-218246.

17.刘静, 闫峻峰, 兰姗, 等. 1632例老年患者使用氨甲环酸注射剂的不良反应报告分析[J]. 中国药物应用与监测, 2022, 19(4): 244-247. [Liu J, Yan JF, Lan S, et al. Analysis of 1632 cases of adverse drug reaction reports in elderly patients using tranexamic acid injection[J]. Chinese Journal of Drug Application and Monitoring, 2022, 19(4): 244-247.] DOI: 10.3969/j.issn.1672-8157. 2022.04.010.

18.Myers SP, Kutcher ME, Rosengart MR, et al. Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism[J]. J Trauma Acute Care Surg, 2019, 86(1): 20-27. DOI: 10.1097/TA. 0000000000002061.

19.Pfizer Inc. CYKLOKAPRON- tranexamic acid injection, solution Pharmacia and Upjohn Company, 1986[EB/OL]. (2021-03) [2022-12-23]. https://labeling.pfizer.com/ShowLabeling.aspx?id=556.

20.Irl H, Kratzer S, Schwerin S, et al. Tranexamic acid impairs hippocampal synaptic transmission mediated by gamma aminobutyric acid receptor type A[J]. Eur J Pharmacol, 2017, 815: 49-55. DOI: 10.1016/j.ejphar.2017.10.001.

21.徐跃峤, 王宁, 胡锦, 等. 重症动脉瘤性蛛网膜下腔出血管理专家共识(2015)[J]. 中国脑血管病杂志, 2015, 12(4): 215-225. [Xu YQ, Wang N, Hu J, et al. Expert consensus on the management of severe aneurysmal subarachnoid hemorrhage (2015)[J]. Chinese Journal of Cerebrovascular Diseases, 2015, 12(4): 215-225.] DOI: 10.3969/j.issn.1672-5921.2015.04.011.

22.中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2019)[J]. 中华神经科杂志, 2019, 52(12): 994-1005. DOI: 10.3760/cma.j.issn.1006-7876.2019. 12.003.

23.中国医师协会内镜医师分会消化内镜专业委员会. 急性非静脉曲张性上消化道出血诊治指南(2018年,杭州)[J]. 中华医学杂志, 2019, 99(8): 571-578. DOI: 10.3760/cma.j.issn.0376-2491.2019.08.003.

24.中华医学会外科学分会脾及门静脉高压外科学组. 肝硬化门静脉高压症食管、胃底静脉曲张破裂出血诊治专家共识(2019版)[J]. 中华消化外科杂志, 2019, 18(12): 1087-1093. DOI: 10.3760/cma.j.issn.1673-9752. 2019.12.001.

25.HALT-IT Trial Collaborators. Effects of a high-dose 24 h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial[J]. Lancet, 2020, 395(10241): 1927-1936. DOI: 10.1016/S0140-6736(20)30848-5.

26.Moharamzadeh P, Ojaghihaghighi S, Amjadi M, et al. Effect of tranexamic acid on gross hematuria: a pilot randomized clinical trial study[J]. Am J Emerg Med, 2017, 35(12): 1922-1925. DOI: 10.1016/j.ajem.2017.09.012.

27.中华医学会妇产科学分会妇科内分泌学组. 异常子宫出血诊断与治疗指南(2022更新版)[J]. 中华妇产科杂志, 2022, 57(7): 481-490. DOI: 10.3760/cma.j.cn112141- 20220421-00258.

28.胡燕军, 朱依敏, 黄荷凤. 功能失调性子宫出血诊治规范[J]. 国际生殖健康/计划生育杂志, 2011, 30(4): 319-321. [Hu YJ, Zhu YM, Huang HF. Guidelines for dysfunctional uterine bleeding[J]. Journal of International Reproductive Health/Family Planning, 2011, 30(4): 319-321.] DOI: 10.3969/j.issn.1674-1889.2011.04.015.

29.北京医师协会呼吸内科专科医师分会咯血诊治专家共识编写组. 咯血诊治专家共识[J]. 中国呼吸与危重监护杂志, 2020, 19(1): 1-11. DOI: 10.7507/1671-6205.201911006.

30.中国康复技术转化及发展促进会, 中国研究型医院学会关节外科学专业委员会, 中国医疗保健国际交流促进会关节疾病防治分会, 等. 中国骨科手术加速康复围手术期氨甲环酸与抗凝血药应用的专家共识 [J]. 中华骨与关节外科杂志, 2019, 12(2): 81-88. DOI: 10.3969/j.issn.2095-9958.2019.02.01.

31.岳辰, 谢锦伟, 蔡东峰, 等. 静脉联合局部应用氨甲环酸减少初次全髋关节置换术围手术期失血的有效性及安全性研究[J]. 中华骨与关节外科杂志, 2015, 8(1): 44-48. [Yue C, Xie JW, Cai DF, et al. Efficacy and safety of intravenous injection combined with topical tranexamic acid for reducing perioperative bleeding during primary total hip arthroplasty: a retrospective study[J]. Chinese Journal of Bone and Joint Surgery, 2015, 8(1): 44-48.] DOI: 10.3969/j.issn.2095-9958.2015.01-009.

32.Lin SY, Chen CH, Fu YC, et al. The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty[J]. J Arthroplasty, 2015, 30(5): 776-780. DOI: 10.1016/j.arth.2014.12.001.

33.山东省药学会循证药学专业委员会. 山东省超药品说明书用药专家共识(2021年版)[J]. 临床药物治疗杂志, 2021, 19(6): 9-40. DOI: 10.3969/j.issn.1672-3384. 2021.06.002.

34.WHO. Recommendation on tranexamic acid for the treatment of postpartum haemorrhage[R]. Geneva: World Health Organization, 2017.