Pharmaceutical care of a child with high-risk neuroblastoma using dinutuximab beta by clinical pharmacists

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Author: Li-Ting YU ¹ Zhuo WANG ² Yi-Jin GAO ² Shun-Guo ZHANG ¹  Ying-Zhong HE ³

Affiliation: 1. Department of Pharmacy, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China 2. Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China 3. Department of Neurology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Keywords: Neuroblastoma Dinutuximab beta Adverse drug reaction Pain Pharmaceutical care

DOI: 10.19960/j.issn.1005-0698.202310010

Reference: Li-Ting YU, Zhuo WANG, Yi-Jin GAO, Shun-Guo ZHANG, Ying-Zhong HE.Pharmaceutical care of a child with high-risk neuroblastoma using dinutuximab beta by clinical pharmacists[J].Yaowu Liuxingbingxue Zazhi,2023, 32(10):1170-1174.DOI: 10.19960/j.issn.1005-0698.202310010.[Article in Chinese]  Copied

Abstract
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Abstract

Clinical pharmacists performed pharmaceutical care for a child with high-risk neuroblastoma who was treated with dinutuximab beta to explore the role of clinical pharmacists in new targeted drug therapy. Adverse reactions such as pain, repeated high fever (heat peak 40℃), capillary leakage syndrome (eyelid edema, reduced blood pressure), diarrhea, hypokalemia (2.74 mmol·L^-1), vomiting occurred successively during the use of dinutuximab beta. The clinician gave the patient symptomatic treatments such as analgesic, antipyretic, anti-infection, diuretic, antidiarrhea, potassium supplement and antiemesis, etc. The clinical pharmacist put forward suggestions on the usage, dosage and dose adjustment of dinutuximab beta, analgesic drug (morphine, gabapentin), antibiotics (cefoperazone sulbactam, voriconazole), antiemesis drug (palonosetron) and other drugs, which were adopted by the clinic. The effectiveness and safety of medication for children were improved.

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