Objective  To sort out and summarize the research hotspots and development trends of the mechanism of natural medicines and traditional Chinese medicines in the treatment acute lung injury, and to provide basis and feasible suggestions for follow-up research.

Methods  The relevant literatures on the mechanism of natural medicines and traditional Chinese medicines in the treatment of acute lung injury in CNKI database were retrieved, and the keywords were visualized analyzed by CiteSpace.

Results  A total of 752 literatures were included, involving 475 keywords, forming 11 representative clusters. The hotspots in this field mainly focus on the anti-inflammatory, anti-oxidation, regulation of autophagy cell and apoptosis mechanisms of natural drugs. In this process, NF-κB was the most frequently involved target. The therapeutic drugs studied included the active ingredients of natural drugs, traditional Chinese medicine and traditional Chinese patent medicine. Metabolomics, autophagy, zebrafish, molecular docking, natural drug active ingredients (naringin, fritillarin A, luteolin, glycyrrhizic acid) were emerging topics of research in recent years, while anti-inflammatory, antioxidant, apoptosis, and traditional Chinese medicine (salvia miltiorrhiza, ligustrazine, astragalus, rhubarb) were classic topics with a long span.

Conclusion  At present, the research of natural medicines and traditional Chinese medicines in the treatment of acute lung injury involves many components and targets. Metabolomics and molecular docking technology will contribute to the systematic study of the mechanism of natural drugs and traditional Chinese medicines.

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