In recent years, the safety of traditional Chinese medicine has attracted more and more attention. Whether drugs can cause liver injury is the focus of drug safety research, it is of great significance to the development and use of traditional Chinese medicine.Immunohistochemical method can be used to localize, qualitatively and quantitatively study the antigen, and plays an important role in the study of drug hepatotoxicity.Through reviewing the reports on hepatotoxicity caused by traditional Chinese medicine and its mechanism in the past years, this paper summarizes the application of immunohistochemistry in the study of hepatotoxicity of traditional Chinese medicine, so as to provide a reference for the application of immunohistochemistry in the safety evaluation of traditional Chinese medicine.

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