This paper reports the clinical pharmacist's participation in the treatment of a patient with lower extremity deep venous thrombosis (DVT) after atrial septal defect (ASD) occlusion. The patient developed lower extremity venous thrombosis after ASD occlusion. The clinical pharmacist evaluated the risk of thrombus and bleeding referring to the domestic and foreign literature and considering the patient's age, symptoms, liver and kidney function and medical history. They suggested that the patient was given antithrombotic therapy of nadroparin calcium injection combined with aspirin. Iliac vein thrombosis and cardiac thrombosis were excluded during hospitalization. The patient's symptoms of lower extremity DVT were significantly improved, hence the antithrombotic therapy was not further adjusted. After the antithrombotic therapy, the swelling in the patient's lower extremities had subsided, and the lower extremity DVT was effectively controlled, with no bleeding points observed throughout the body. The patient was discharged from hospital, and the clinical pharmacist suggested the antithrombotic therapy plan that was aspirin combined with rivaroxaban for 3-6 months, and advised the patient to pay attention to the bleeding tendency during medication. The clinician adopted the suggestion. After discharge, venous bilateral doppler ultrasonography of lower extremity showed no evidence of deep vein thrombosis. The clinical pharmacist assisted clinicians to develop individualized antithrombotic therapy and conducted the whole process of pharmaceutical care. This controlled the patient’s condition effectively, ensured the safety and effectiveness of drug use, and could provide reference for the management of antithrombotic therapy in patients with venous thrombosis after ASD occlusion.

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