A case of kidney injury induced by capecitabine tablets

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Author: Juan PAN ¹ Xian-Bin WANG ² Ling-Zhi ZHOU ¹  Zu-Yi LI ¹

Affiliation: 1. Department of Pharmacy, Liuyang Hospital of Traditional Chinese Medicine, Liuyang 410300, Hunan Province, China 2. Department of Anorectal Breast, Liuyang Hospital of Traditional Chinese Medicine, Liuyang 410300, Hunan Province, China

Keywords: Capecitabine Kidney injury Adverse drug reaction Case report

DOI: 10.19960/j.issn.1005-0698.202302016

Reference: Juan PAN, Xian-Bin WANG, Ling-Zhi ZHOU, Zu-Yi LI.A case of kidney injury induced by capecitabine tablets[J].Yaowu Liuxingbingxue Zazhi,2023, 32(2): 237-240.DOI: 10.19960/j.issn.1005-0698.202302016.[Article in Chinese]  Copied

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Abstract

A 72-year-old male patient with rectal cancer received single-agent chemotherapy with capecitabine tablets (the dosage regimen was 1.5 g in the morning and 1.75 g in the evening, 2 week medication followed by 1 week discontinuation, 3 weeks was a cycle). On the second day after discontinuation of the third cycle of capecitabine, oliguria began and retching developed five days later. Laboratory tests showed serum creatinine 226 μmol·L^-1, urea 14.40 mmol·L^-1, and uric acid 601 μmol·L^-1. The diagnosis of kidney injury was considered to be related to capecitabine tablets. Symptomatic treatment such as rehydration and kidney protection were given. Four days later, the symptoms above-mentioned in the patient were improved obviously, and on the 7th day after admission, his renal function index basically returned to normal.

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