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Efficacy of edaravone dexborneol combined with alteplase in the treatment of acute ischemic stroke: a randomized controlled trial

Published on Oct. 01, 2024Total Views: 945 times Total Downloads: 259 times Download Mobile

Author: WU Weijie 1# SUN Zihui 1, 2# XU Liang’e 1 HUANG He 1 HUANG Xuerong 1

Affiliation: 1. Department of Neurology, The Third Affiliated Hospital, Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China 2. School of Mental Health, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China

Keywords: Edaravone dexborneol Alteplase Acute ischemic stroke Intravenous thrombolysis Efficacy

DOI: 10.12173/j.issn.1005-0698.202404060

Reference: WU Weijie, SUN Zihui, XU Liang’e, HUANG He, HUANG Xuerong.Efficacy of edaravone dexborneol combined with alteplase in the treatment of acute ischemic stroke: a randomized controlled trial[J].Yaowu Liuxingbingxue Zazhi,2024, 33(9):978-985.DOI: 10.12173/j.issn.1005-0698.202404060.[Article in Chinese]

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Abstract

Objective  To explore the clinical efficacy of edaravone dexborneol combined with intravenous thrombolysis with alteplase, in the treatment of patients with acute ischemic stroke (AIS).

Methods  The patients with AIS undergoing intravenous thrombolysis with alteplase between January 7, 2021 and December 31, 2022 were enrolled  and randomly divided into observation group and control group. The control group was treated with standard treatment according to the AIS guidelines, and the observation group was treated with edaravone dexborneol injection within 48 hours from thrombolysis to the onset of the disease on the basis of the treatment in the control group. 7-day post-thrombolysis National Institutes of Health stroke scale (NIHSS), discharged NIHSS, difference between 7-day post-thrombolysis NIHSS and pre-thrombolysis NIHSS, and 3-month all-cause mortality and 3-month poor prognosis ratio were compared between the two groups.

Results  A total of 232 patients  with AIS were randomly allocated to the observation group (n=116) and the control group (n=116). The differences between the two groups were not statistically significant for 7-day post-thrombolysis NIHSS and difference between 7-day post-thrombolysis NIHSS and pre-thrombolysis NIHSS (P>0.05), and there were statistical differences in distribution of the discharged NIHSS score between the observation group and control group [2.0 (0, 3.0) vs. 2.0 (1.0, 5.0), P<0.05]. The 3-month poor prognosis ratio was significantly lower in the observation group than in the control group (12.1% vs. 28.4%; OR=0.252, 95%CI 0.105 to 0.602 , P=0.002).

Conclusion  Edaravone dexborneol enhances the efficacy of AIS undergoing intravenous thrombolysis with alteplase and improves the 3-month outcome of patients.

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References

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