Multicenter retrospective investigation and analysis of the rationality of the application of human albumin in cardiac surgery during the perioperative period

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Author: PAN Wenfei ¹ YU Huan ¹ DANG Dasheng ² CHEN Lijuan ³ LI Te ⁴ SHI Tianlu ⁵ HUANG Banghua ⁶ LI Boxia ⁷ GONG Xiaoxue ⁸  WANG Ying ¹

Affiliation: 1. Department of Pharmacy, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China 2. Department of Pharmacy, the Northern Theater Command General Hospital of Chinese PLA, Shenyang 110016, China 3. Department of Pharmacy, Tianjin Chest Hospital, Tianjin 300050, China 4. Department of Pharmacy, Fuwai Yunnan Cardiovascular Hospital, Kunming 650102, China 5. Department of Pharmacy, The First Affiliated Hospital of USTC (Anhui Provincial Hostipal), Hefei 230001, China 6. Department of Pharmacy, The First People's Hospital of Yunnan Province, Kunming 650032, China 7. Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou 730000, China 8. Institute of Clinical Pharmacy and Pharmacology, Jining First People’s Hospital, Jining 272000, Shandong Province, China

Keywords: Human serum albumin Clinical application Retrospective study Rational drug use

DOI: 10.12173/j.issn.1005-0698.202305040

Reference: PAN Wenfei, YU Huan, DANG Dasheng, CHEN Lijuan, LI Te, SHI Tianlu, HUANG Banghua, LI Boxia, GONG Xiaoxue, WANG Ying.PAN Wenfei, YU Huan, DANG Dasheng, CHEN Lijuan, LI Te, SHI Tianlu, HUANG Banghua, LI Boxia, GONG Xiaoxue, WANG YingMulticenter retrospective investigation and analysis of the rationality of the application of human albumin in cardiac surgery during the perioperative period[J].Yaowu Liuxingbingxue Zazhi,2024, 33(2):176-183.DOI:10.12173/j.issn.1005-0698.202305040.[Article in Chinese]  Copied

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Abstract

Objective To investigate the clinical application of perioperative human serum albumin (HSA) in cardiac surgery in multiple regions in China, and to evaluate the rationality of its clinical application in conjunction with the clinical guidelines, in order to provide a reference for promoting the rational application of HSA.

Methods The medical records of patients who underwent cardiac surgery from April to June 2019 in eight hospitals across the country were retrospectively collected. The statistical information on patients’ general information, the dosage, course of treatment, and cost of HSA, and the serum albumin level before and after medication was analyzed to evaluate the use of HSA. Relevant evaluation criteria were established, and the rationality of its medication was evaluated.

Results Data from a total of 449 patients were included for analysis, the appropriate rate of medication was 81.1%. The course of medication was mostly >2-5 days and the total amount of HSA was mostly 50-99 g. The main purpose of medicaiton were improving colloid osmotic pressure, reducing exudation to improve interstitial edema, postoperative volume expansion.

Conclusion Clinical attention should be paid to ensure the rational application of HSA in cardiac surgery during the perioperative period and prevent the abuse of blood products.

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