This article reported that clinical pharmacists participated in the anti-infection treatment process of a patient with fever after intracranial aneurysm operation. The initial fever in the patient caused by arachnoid hemorrhage was non-infectious fever. Then followed by intracranial infections, the intravenous regimen of vancomycin and meropenem was optimized according to clinically relevant guidelines and the blood-brain barrier permeability of antimicrobials. Later, Escherichia coli was reported via the cerebrospinal fluid culture, and the patient with intracranial infection was cured by step-down therapy with ceftazidime. During hospitalization, the patient experienced an adverse event of demyelinating myelitis, which was considered to be related to the excessive single dose of intrathecal gentamicin. The intrathecal administration was promptly discontinued, and eventually the patient recovered well in muscle power. Throughout the entire treatment process, clinical pharmacists assisted physicians in providing patient with an individualized treatment plan and provided reference for the safe, effective, and rational use of antibiotics.

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