With the increasing aging of the population, the number of patients with osteoarthritis is increasing year by year, posing a serious threat to human health. However, up to now, there is a lack of satisfactory clinical treatment for osteoarthritis. Silk protein is a natural polymer material with good biocompatibility, biodegradability and excellent mechanical properties, which is widely used in the field of bone tissue engineering. In recent years, with the continuous research on silk fibroin, more and more scholars have started to try to use silk fibroin hydrogel as a carrier for the treatment of osteoarthritis, and the results show that it has great potential for application in the treatment of osteoarthritis. This paper summarizes the research progress so far on the pathogenesis of osteoarthritis, commonly used drugs and the treatment of osteoarthritis with silk fibroin hydrogels, and lays the foundation for further exploration of the application of silk protein hydrogel in the treatment of osteoarthritis.

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