Efficacy of nimodipine combined with statins in the treatment of patient with subarachnoid hemorrhage and its impact on neurological function: a Meta-analysis

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Author: DU Xuebing ¹ WANG Hongyan ² ZHU Xiaodong ¹ WU Jiajun ³ MA Ziyang ³  CAO Jing ⁴

Affiliation: 1. Department of Medical Records, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China 2. Department of Laboratory Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China 3. School of Information Management and Information Systems, Capital Medical University, Beijing 100069, China 4. Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China

Keywords: Nimodipine Statins Subarachnoid hemorrhage Delayed cerebral ischemia Meta-analysis

DOI: 10.12173/j.issn.1005-0698.202510049

Reference: DU Xuebing, WANG Hongyan, ZHU Xiaodong, WU Jiajun, MA Ziyang, CAO Jing. Efficacy of nimodipine combined with statins in the treatment of patient with subarachnoid hemorrhage and its impact on neurological function: a Meta-analysis[J]. Yaowu Liuxingbingxue Zazhi, 2026, 35(3): 318-326. DOI: 10.12173/j.issn.1005-0698.202510049.[Article in Chinese]  Copied

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Abstract

Objective To systematically review the efficacy of nimodipine combined with statins in the treatment of patients with subarachnoid hemorrhage (SAH) and its impact on neurological function.

Methods PubMed, Embase, Cochrane Library, CNKI, SinoMed, VIP, and WanFang Data were searched electronically for randomized controlled trials (RCTs) comparing nimodipine combined with statins versus nimodipine alone in patients with SAH from inception to September 30, 2025. Two researchers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. Meta-analysis was performed using RevMan 5.4 and R 4.4.2 software.

Results A total of 17 RCTs involving 1,532 patients were included. The results of the Meta-analysis showed that nimodipine combined with statins significantly improved the clinical effectiveness rate compared with nimodipine alone [OR=3.51, 95%CI (2.55, 4.84), P<0.05]. Subgroup analysis by statin type revealed that both atorvastatin and simvastatin were beneficial, with no statistically significant difference between subgroups (P=0.505). The combined therapy reduced the degree of neurologic deficit [SMD=-1.92, 95%CI (-2.67, -1.16), P<0.001]. The incidence of adverse reactions was not statistically significant between the nimodipine combined with statins group and nimodipine alone group [OR=0.60, 95%CI (0.28, 1.29), P>0.05].

Conclusion Nimodipine combined with statins is superior to nimodipine alone in preventing delayed cerebral ischemia and improving neurological function in SAH patients, and it has good safety. Due to the limited number and quality of included studies, the above conclusions still need to be verified by large-sample, multicenter and high-quality RCTs.

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