Drug use evaluation of prothrombin complex concentrate based on weighted TOPSIS method

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Author: Bo ZHANG ^1# Li LI ^2# Qi YAN ¹ Shi-Cai CHEN ³  Jin-Hua ZHANG ⁴

Affiliation: 1. Department of Pharmacy, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu Province, China 2. Department of Pharmacy, Guizhou Provincial People’s Hospital, Guiyang 550002, China 3. Department of Pharmacy, Beijing Luhe Hospital, Captial Medical Univeisity, Beijing 101149, China 4. Department of Pharmacy, Fujian Maternity and Child Health Hospital, Fuzhou 350001, China #Co-first author: Bo ZHANG and Li LI

Keywords: Prothrombin complex concentrate Weighted TOPSIS method Attribute hierarchical model Drug use evaluation

DOI: 10.19960/j.issn.1005-0698.202312003

Reference: Bo ZHANG, Li LI, Qi YAN, Shi-Cai CHEN, Jin-Hua ZHANG.Drug use evaluation of prothrombin complex concentrate based on weighted TOPSIS method[J].Yaowu Liuxingbingxue Zazhi,2023, 32(12): 1338-1346.DOI: 10.19960/j.issn.1005-0698.202312003.[Article in Chinese]  Copied

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Abstract

Objective To establish the detailed rules for the drug use evaluation (DUE) of prothrombin complex concentrate (PCC) , and evaluate the use of PCC by weighted TOPSIS method to provide references for its clinical rational application.

Methods Based on the instructions of PCC and referring to relevant data, the DUE standard rules were established, and weighted TOPSIS method was used to evaluate the rationality of medication in the cases of in patients who used PCC from January 2021 to December 2021 in the Affiliated Hospital of Xuzhou Medical University.

Results A total of 121 cases were included, the relative weights of the three indicators were as follows: coagulation function, dosage, interval, course of treatment and, diagnosis, progress notes drug interaction, with the weights of 0.095 2, 0.091 3, 0.091 3, 0.091 3, 0.089 7, 0.084 1 and 0.081 7 respectively. There were 21 cases (17.36%) with reasonable medical records, 39 cases (32.23%) with basically reasonable medical records, and 61 cases (50.41%) with unreasonable medical records. The main unreasonable problems were manifested in indications, usage and dosage, and drug interaction.

Conclusion The DUE criteria of PCC established is more scientific, practical and feasible. The indications, usage, dosage, and drug interaction of PCC remain unreasonable criteria, and pharmaceutical intervention should be carried out to promote its rational use.

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