Acute attack of critical asthma caused by ketochromate tromethamine injection: a case report

Published on Apr. 27, 2023Total Views: 820 times Total Downloads: 368 times Download Mobile

Affiliation: 1. Department of Pharmacy, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China 2. Department of Respiratory Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China

Keywords: Ketorolac tromethamine The elderly Bronchial asthma Adverse drug reactions

DOI: 10.19960/j.issn.1005-0698.202304014

Reference: Xu-Hui PU, Zheng-Ya WANG.Acute attack of critical asthma caused by ketochromate tromethamine injection: a case report[J].Yaowu Liuxingbingxue Zazhi,2023, 32(4): 476-480.DOI: 10.19960/j.issn.1005-0698.202304014.[Article in Chinese]  Copied

Abstract
Full-text
References

Abstract

A 67-year-old male patient was given ketorolac tromethamine injection (90mg) and 0.9% sodium chloride injection (250 mL) intravenously once a day after the operation of the right incarcerated inguinal hernia. The patient had dyspnea and sweating at 120 minutes after the first administration, with a heart rate of 120 times/min and a respiration rate of 32 times/min. The patient’s blood oxygen saturation was 88% (nasal catheterization with oxygen at 3 L·min^-1), and was lethargic, with positive triplectral signs, audible laryngeal sounds, and loud wheezing sounds in both lungs. The diagnosis was an acute attack of severe bronchial asthma. The drug was stopped and the patient was treated with dexamethasone and aminophylline injections. After 1 hour, the patient's dyspnea improved. The heart rate was 102 times/min, the breathing rate was 28 times/min, the blood oxygen saturation was 100% (oxygen absorption by mask was 5 L·min^-1), and his consciousness was clear. After 1 day, the patient had no dyspnea, and no wheezing sound was heard in both lungs. By correlation analysis, the causal relationship between the acute asthma attack and ketorolac ambulatol injection was evaluated as "very possible".

Full-text

Please download the PDF version to read the full text: download

References

1.Corey KB, Cahill KN. Aspirin-exacerbated respiratory disease: aunique case of drug hypersensitivity[J]. Immunol Allergy Clin North Am, 2022, 42(2): 421-432. DOI: 10.1016/j.iac.2021.12.005.

2.原国家卫生部. 药品不良反应报告和监测管理办法(卫生部令第81 号)[EB/OL]. (2011-05-04)[2019-04-21]. http://www.nhc.gov.cn/fzs/s3576/201105/ac4ab24c135a43379f2af1694457f65e.shtml.

3.White AA, Stevenson DD. Aspirin-exacerbated respiratory disease[J]. N Engl J Med, 2018, 379(11): 1060-1070. DOI: 10.1056/NEJMra1712125.

4.Divekar R, Hagan J, Rank M, et al. Diagnostic utility of urinary LTE4 in asthma, allergic rhinitis, chronic rhinosinusitis, nasal polyps, and aspirin sensitivity[J]. J Allergy Clin Immunol Pract, 2016, 4(4): 665-670. DOI: 10.1016/j.jaip.2016.03.004.

5.Hayashi H, Fukutomi Y, Mitsui C, et al. Omalizumab for aspirin hypersensitivity and leukotriene overproduction in aspirin-exacerbated respiratory disease. A randomized controlled trial[J]. Am J Respir Crit Care Med, 2020, 201(12): 1488-1498. DOI: 10.1164/rccm.201906-1215OC.

6.Mastalerz L, Sanak M, Gawlewicz-Mroczka A, et al. Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity[J]. Thorax, 2008, 63(1): 27-34. DOI: 10.1136/thx.2007.080903.

7.Morales DR, Lipworth BJ, Guthrie B, et al. Safety risks for patients with aspirin-exacerbated respira-tory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhib-itors: Meta-analysis of controlled clinical trials[J]. J Allergy Clin Immunol, 2014, 134(1): 40-45. DOI: 10.1016/j.jaci.2013.10.057.

8.何振凤, 鲁云兰. 酮咯酸的临床不良反应[J]. 中国新药杂志, 1995(2): 42-43. [He ZF, Lu YL. Clinical adverse ef-fects of ketorolac[J]. Chinese Journal of New Drugs, 1995(2): 42-43.] DOI: CNKI:SUN:ZXYZ.0.1995-02-014.

9.Campobasso CP, Procacci R, Caligara M. Fatal adverse reaction to ketorolac tromethamine in asth-matic patient[J]. Am J Forensic Med Pathol, 2008, 29(4): 358-363. DOI: 10.1097/PAF.0b013e318185a00a.

10.Chen AH, Bennett CR. Ketorolac-induced bronchospasm in an aspirin-intolerant patient[J]. Anesth Prog, 1994, 41(4): 102-107. http://www.stats.gov.cn/tjsj/zxfb/202102/t20210227_1814154.html.

11.Sitenga GL, Ing EB, Van Dellen RG, et al. Asthma caused by topical application of ketorolac[J]. Ophthalmology, 1996, 103(6): 890-892. DOI: 10.1016/s0161-6420(96)30591-5.

12.王淑云, 窦菲菲, 刘丽萍,等. 鼻黏膜激发试验诊断非甾体抗炎药加重呼吸道疾病一例报告[J]. 中华临床免疫和变态反应杂志, 2021, 15(6): 664-668. [Wang SY, Dou FF, Liu LP, et al. Nasal mucosal stimulation test for diag-nosis of respiratory disease aggravated by non-steroidal anti-inflammatory drugs: a case report[J]. Chinese Journal of Allergy & Clinical Immunology, 2021, 15(6): 664-668.] DOI: 10.3969/j.issn.1673-8705.2021.06.010.

13.沈秉正, 宋金春, 施偲, 等. 合并用药含醇辅料导致双硫仑样不良反应12例分析[J]. 药学与临床研究, 2013, 21(6): 680-681. [Shen BZ, Song JC, Shi S, et al. Analysis on 12 cases of disulfiram-like reaction caused by drug excipients in drug combination[J]. Pharmaceutical and Clinical Research, 2013, 21(6): 680-681.] DOI: 10.13664/j.cnki.pcr.2013.06.023.

14.文力, 韩兴, 任爽, 等. 老年双硫仑样反应患者的临床特征分析[J]. 中华老年医学杂志, 2019, 38(5): 537-541. [Wen L, Han X, Ren S, et al. Clinical characteristics of elderly patients with disulfiram-like reaction: a retro-spective analysis of 19 cases[J]. Chinese Journal of Geriatrics, 2019, 38(5): 537-541.] DOI: 10.3760/cma.j.issn.0254-9026.2019.05.016.

15.中华医学会麻醉学分会老年人麻醉与围术期管理学组, 中华医学会麻醉学分会疼痛学组国家老年疾病临床医学研究中心, 国家老年麻醉联盟. 老年患者围手术期多模式镇痛低阿片方案中国专家共识(2021版)[J]. 中华医学杂志, 2021, 101(3): 170-184. DOI: 10.3760/cma.j.cn112137-20200520-01600.

16.宋佳伟, 汪龙, 施朕善, 等. 酮咯酸氨丁三醇注射液药物利用评价标准的建立及应用[J]. 中国现代应用药学, 2020, 37(21): 2659-2663. [Song JW, Wang L, Shi ZS, et al. Establishment and application of drug use evalua-tion criteria for ketorolac tromethamine injection[J]. Chinese Journal of Modern Applied Pharmacy, 2020, 37(21): 2659-2663.] DOI: 10.13748/j.cnki.issn1007-7693.2020.21.018.

17.张冠军. 酮咯酸氨丁三醇注射液临床应用的药物相关问题分析[J]. 中国药业, 2022, 31(7): 121-124. [Zhang GJ. Drug-related problem in clinical application of ketorolac tromethamine injection[J]. China Pharmaceu-ticals, 2022, 31(7): 121-124.] DOI: 10.3969/j.issn.1006-4931.2022.07.031.