Objective To investigate the effect of bone-peptide injection on improving positive aging attitudes in elderly patients with knee osteoarthritis (KOA).

Methods Clinical data of elderly patients with KOA were retrospectively collected. Patients were divided into the bone-peptide group (conventional therapy plus intra-articular bone peptide injection) and the control group (conventional therapy alone). Changes in the Attitudes to Ageing Questionnaire (AAQ), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), and Hospital Anxiety and Depression Scale (HADS) scores were compared between the two groups before and after treatment. Multivariate Logistic regression and multiple linear regression models were used to investigate the factors influencing the formation of positive aging attitudes and the degree of improvement in aging attitudes, respectively.

Results A total of 125 patients were included, including 54 in the bone-peptide group and 71 in the control group. After treatment, the bone‑peptide group demonstrated significantly greater improvements in total AAQ score, WOMAC score, VAS score, as well as HADS‑anxiety and HADS‑depression scores compared with the control group (all P<0.001). Multivariate Logistic regression showed that bone‑peptide treatment [OR=5.67, 95%CI(1.84, 17.46)], WOMAC improvement [OR=1.07, 95%CI(1.02, 1.13)], HADS‑depression improvement [OR=1.47, 95%CI(1.03, 2.11)], and comorbid diabetes mellitus [OR=0.37, 95%CI(0.14, 0.97)] were influencing factors for achieving positive aging attitudes. Multiple linear regression revealed that bone‑peptide treatment, HADS‑anxiety improvement, and comorbid diabetes mellitus were correlated with the degree of AAQ improvement.

Conclusion Intra-articular bone-peptide injection can effectively improve joint function and emotional status in elderly KOA patients, and serves as an independent influencing factor for positive aging attitudes.

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