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Home Articles Vol 35,2026 No.8 Detail

Ischemic bowel disease caused by compound Huangdai tablets: a case report

Published on Sep. 03, 2026Total Views: 15 times Total Downloads: 1 times Download Mobile

Author: JIN Hao 1, 2 SONG Yulin 3 YAO Yanxue 4 LI Ting 5 WANG Yanyan 2

Affiliation: 1.Department of Pharmacy, the 90lst Hospital of the PLA Joint Logistics Support Force, Hefei 230031, China 2.Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei 230031, China 3.Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230031, China 4.Department of Pharmacy, Anhui Zhongke Gengjiu Hospital, Hefei 230041, China 5.Department of Pharmacy, Hefei Eighth People's Hospital, Hefei 238000, China

Keywords: Ischemic colitis Compound Huangdai Tablets Adverse drug reaction

DOI: 10.12173/j.issn.1005-0698.202512060

Reference: Jin H, Song YL, Yao YX, et al. Ischemic bowel disease caused by compound Huangdai tablets: a case report[J]. Chinese Journal of Pharmacoepidemiology, 2026, 35(8): 960-964.DOI: 10.12173/j.issn.1005-0698.202512060.[Article in Chinese]

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Abstract

A 54-year-old male patient with acute promyelocytic leukemia developed left lower abdominal pain and bright red bloody stools 5 times per day after taking compound Huangdai tablets for 17 days. Laboratory tests showed a white blood cell count of 13.02×109·L-1, neutrophil percentage of 80%, hemoglobin of 158 g·L-1, and C-reactive protein of 3.68 mg·L-1. Fecal occult blood testing was positive. Diagnosis of ischemic enteropathy was confirmed via sigmoidoscopy and abdominal CT. Compound Huangdai tablets were discontinued, and the patient was treated with fluid supplementation, anticoagulation, and anti-infection. The patient's abdominal pain resolved, the bloody stools ceased, and he resumed a normal diet, with his stool turning yellow. Using Naranjo's Adverse Drug Reaction Scale, the association between ischemic bowel disease and compound Huangdai tablets was assessed as likely related. This study comprehensively analyzed the clinical features and treatment process of ischemic enteropathy induced by compound Huangdai tablets, aiming to provide references for safe clinical medication.

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