Drug use evaluation of recombinant human coagulation factor VIIa based on weighted TOPSIS method

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Author: Guo-Quan CHEN ^1, ² Li JIANG ^2, ³  Jin-Hua ZHANG ^2, ⁴

Affiliation: 1. Department of Pharmacy, Affiliated Jinhua Hospital, Medical College of Zhejiang University, Jinhua 321000, Zhejiang Province, China 2. Department of Pharmacy, Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China 3. Department of Pharmacy, Minhou County People’s Hospital, Fuzhou 350119, China 4. Department of Pharmacy, Fujian Provincial Maternity and Children’s Hospital, Fuzhou 350001, China

Keywords: Weighted TOPSIS method Recombinant human coagulation factor Ⅶa Drug use evaluation

DOI: 10.19960/j.issn.1005-0698.202304004

Reference: Guo-Quan CHEN, Li JIANG, Jin-Hua ZHANG.Drug use evaluation of recombinant human coagulation factor Ⅶa based on weighted TOPSIS method[J].Yaowu Liuxingbingxue Zazhi,2023, 32(4):384-390.DOI: 10.19960/j.issn.1005-0698.202304004.[Article in Chinese]  Copied

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Abstract

Objective To establish the evaluation criteria for the use of recombinant human coagu-lation factor Ⅶa (rFⅦa), and to evaluate the rationality of clinical practice of rFⅦa.

Methods The rFⅦa evaluation criteria was established based on literature survey and expert consultation. 73 cases of rFⅦa archived medical records in the Affiliated Union Hospital of Fujian Medical University and evaluated by weighted TOPSIS method were collected.

Results Of the 73 cases, 4 cases (5.48%) had relative proximity (Ci)≥80%, 55 cases (75.34%) had 60%≤Ci<80%, and 14 cases (19.18%) had Ci<60%. The main unrea-sonable evaluation indicators were indications (68.5%), dose and duration (63.0%) and adverse effect monitoring (43.8%).

Conclusion The DUE criteria of rFⅦa is practical and scientific. The application of rFⅦa for tumor patients is basically reasonable according to the weighted TOPSIS method. However, there are still some problems, mainly in terms of abusive indications for use, low dosage and lack of coagulation indicators monitoring.

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