Pharmaceutical practice of acute liver injury in a patient with nintedanib-induced lung cancer complicated with interstitial pneumonia

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Author:  ZHANG Juan ^1, ² SHEN Lihuan ^2, ³ LIU Jiyong ^1, ²  WANG Chunmin ^1, ²

Affiliation: 1. Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China 3. Department of Critical Care, Fudan University Shanghai Cancer Center, Shanghai 200032, China

Keywords: Nintedanib Lung cancer with interstitial pneumonia Acute liver injury Pharmaceutical practice

DOI: 10.12173/j.issn.1005-0698.202407015

Reference: ZHANG Juan, SHEN Lihuan, LIU Jiyong, WANG Chunmin.Pharmaceutical practice of acute liver injury in a patient with nintedanib-induced lung cancer complicated with interstitial pneumonia[J].Yaowu Liuxingbingxue Zazhi,2024, 33(10):1178-1182.DOI: 10.12173/j.issn.1005-0698.202407015.[Article in Chinese]  Copied

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Abstract

This article reports the pharmacotherapy process of a clinical pharmacist participating in the treatment of acute liver injury caused by nintedanib in a patient with lung cancer complicated with interstitial pneumonia. Clinical pharmacist analyzed the rapid increase of liver enzymes in patients by excluding their past drug use history, stopping suspicious drugs and searching domestic and foreign literature, and determined that the association with nidanib was very likely according to RUCAM scale. The clinical pharmacies suggesteded stopping nintedanib and taking liver protection treatment actively. The clinician adopted the suggestion, and finally the patient’s liver function improved after 20 days of treatment. Clinical pharmacists demonstrate their value by analyzing the causes and characteristics of liver injury in patients, assisting physicians in the timely identification and management of adverse reactions, and participating in clinical practice. This article can provide a reference for the diagnosis and treatment of similar cases of acute liver injury.

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References

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