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A case clinical analysis and pharmaceutical care of severe complications of multi-space infection in patients with head and neck tumors

Published on Sep. 28, 2023Total Views: 441 times Total Downloads: 211 times Download Mobile

Author: Yao-Dong PING 1, 2 Xiao-Long XU 3 Bao-Min ZHENG 3 Li-Feng ZHAO 2 Ben-Ben ZHU 2

Affiliation: 1. Department of Pharmacy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China 2. Department of Pharmacy, Peking University Cancer Hospital Inner Mongolia Hospital, Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010020, China 3. Department of Radiotherapy, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China

Keywords: Head and neck tumors Multi-space infection Antibacterial drug Pharmaceutical care

DOI: 10.19960/j.issn.1005-0698.202309005

Reference: Yao-Dong PING, Xiao-Long XU, Bao-Min ZHENG, Li-Feng ZHAO, Ben-Ben ZHU.A case clinical analysis and pharmaceutical care of severe complications of multi-space infection in patients with head and neck tumors[J].Yaowu Liuxingbingxue Zazhi,2023, 32(9): 991-996.DOI: 10.19960/j.issn.1005-0698.202309005.[Article in Chinese]

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Abstract

Clinical pharmacists participated in the treatment of severe complications of oral maxillofacial and neck space infection in a patient with recurrent adenoid cystic carcinoma of the left upper jaw after systemic chemotherapy combined with targeted therapy. Clinical pharmacists analyzed the risk factors of multiple space infection and the distribution characteristics of pathogenic bacteria by referring to literature data, and determined protocols for imipenem cilastatin plus clindamycin in the acute phase and moxifloxacin plus fosfomycin in the stable phase, and the clinician adopted this opinion. Then the infection was effectively controlled and the condition was discharged. Through consultation, clinical pharmacists assisted doctors to develop individualized treatment plans, provided reference for the safe, effective and rational use of antibiotics.

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References

1.Jung J, Oh Y, Cha S, et al. An analysis of contributing factors of head and neck space infections of odontogenic origin: a long-term retrospective clinical study (including COVID-19 pandemic period)[J]. Med Oral Patol Oral Cir Bucal, 2023, 18: 26018. DOI: 10.4317/medoral.26018.  

2.Shiraishi K, Kasai H, Saito M, et al. Case of a deep neck abscess during treatment for COVID-19[J]. Am J Case Rep, 2022, 23: e936034. DOI: 10.12659/AJCR.936034.

3.Desa C, Tiwari M, Pednekar S, et al. Etiology and complications of deep neck space infections: a hospital based retrospective study[J]. Indian J Otolaryngol Head Neck Surg, 2023, 75(2): 697-706. DOI: 10.1007/s12070-022-03428-z.

4.郑宏雨, 李紫璇, 牛志兴, 等. 口腔颌面部及颈部多间隙感染合并下行性坏死性纵隔炎多学科协作诊疗的回顾性分析[J]. 中华口腔医学杂志, 2020, 55(12): 952-957. [Zheng HY, Li ZX, Niu ZX, et al. Retrospective analysis of the effectiveness of treating multi-space infection combined with descending necrotizing mediastinitis at oral maxillofacial and cervical region via multidisciplinary team collaboration[J]. Chinese Journal of Stomatology, 2020, 55(12): 952-957.] DOI: 10.3760/cma.j.cn112144-20200217-00062.

5.朱珊, 宋绍华, 李学玉, 等. 口腔颌面部间隙感染的病原学分析及危险因素研究[J]. 中华医院感染学杂志, 2017, 27(13): 3052-3054, 3058. [Zhu S, Song SH, Li XY, et al. Etiology of oral and maxillofacial space infections and risk factor[J]. Chinese Journal of Nosocomiology, 2017, 27(13): 3052-3054, 3058.] DOI: 10.11816/cn.ni.2017- 170218.

6.Buckley J, Harris AS, Addams-Williams J. Ten years of deep neck space abscesses[J]. J Laryngol Otol, 2019, 133(4): 324-328. DOI: 10.1017/S0022215119000458.

7.王愿林, 程莉, 王和平, 等. 口腔颌面部间隙感染患者治疗的临床研究[J]. 中华医院感染学杂志, 2016, 26(7): 1606-1608. [Wang YL, Cheng L, Wang HP, et al. Clinical study on treatment of patients with oral and maxillofacial space infections[J]. Chinese Journal of Nosocomiology, 2016, 26(7): 1606-1608.] DOI: 10.11816/cn.ni.2016-15278.

8.岳寒, 王勇奇. 探析血液恶性肿瘤患者化疗后口腔感染的相关危险因素[J]. 中华肿瘤防治杂志, 2016, 23(S2): 77-78. [Yue H, Wang YQ. Risk factors of oral infection in patients with hematological malignancies after chemotherapy[J]. Chinese Journal of Cancer Prevention and Treatment, 2016, 23(S2): 77-78.] DOI: 10.16073/j.cnki.cjcpt.2016.s2.037.

9.Ono T, Suzuki S, Kohda H, et al. Ability of mastication and swallowing of the old people in the rehabilitation hospital[J]. J Chromatogr Sci, 2015, 9(2): 709-723. DOI: 10.1111/j.1741-2358.2003.00024.x.

10.Boyanova L, Kolarov R, Gergova G, et al. Anaerobic bacteria in 118 patients with deep-space head and neck infections from the University Hospital of Moxillofacial Surgery, Sofia, Bulgaria[J]. J Med Microbiol, 2006, 55(9): 1285-1289. DOI: 10.1099/jmm.0.46512-0.

11.张志愿, 主编. 口腔颌面外科学[M]. 北京: 人民卫生出版社, 2012: 177-216.

12.Wu JH, Li X, Chen GP, et al. Changing trends of deep neck infections in southern China: a review of 127 cases[J]. Sci Prog, 2021, 104(2): 1-13. DOI: 10.1177/0036850 4211028367.

13.Karkos PD, Leong SC, Beer H, et al. Challenging airways in deep neck space infections[J]. Am J Otolaryngol, 2007, 28(6): 415-418. DOI: 10.1016/j.amjoto.2006.10.012.

14.Cortés-Penfield N, Ryder JH. Should linezolid replace clindamycin as the adjunctive antimicrobial of choice in group A streptococcal necrotizing soft tissue infection and toxic shock syndrome? a focused debate[J]. Clin Infect Dis. 2023, 76(2): 346-350. DOI: 10.1093/cid/ciac720.

15.Van Driel ML, De Sutter AI, Thorning S, et al. Different antibiotic treatments for group A streptococcal pharyngitis[J]. Cochrane Database Syst Rev, 2021, 3(3): CD004406. DOI: 10.1002/14651858.CD004406.pub5.

16.Hamada S, Nakajima M, Kaszynski RH, et al. Association between adjunct clindamycin and in-hospital mortality in patients with necrotizing soft tissue infection due to group A Streptococcus: a nationwide cohort study[J]. Eur J Clin Microbiol Infect Dis, 2022, 41(2): 263-270. DOI: 10.1007/s10096-021-04376-2.

17.Roussos N, Karageorgopoulos DE, Samonis G, et al. Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections[J]. Int J Antimicrob Agents, 2009, 34(6): 506-515. DOI: 10.1016/j.ijantimicag.2009.08.013.

18.Falagas ME, Vouloumanou EK, Samonis G, et al. Fosfomycin[J]. Clin Microbiol Rev, 2016, 29(2): 321-347. DOI: 10.1128/CMR.00068-15.

19.张应龙, 刘维, 龙宇, 等. 中性粒细胞百分比及C-反应蛋白在颈部多间隙感染诊断中的应用[J].中华医院感染学杂志, 2021, 29(15): 2343-2545. [Zhang YL, Liu W, Long Y, et al. Value of percentage of neutrophils and C-reactive protein in diagnosis of patients with neck multiple interstitial infection[J]. Chinese Journal of Nosocomiology, 2021, 29(15): 2343-2545.] DOI: 10.11816/cn.ni.2019-182547.

20.刘巧荣, 石磊, 路兴华, 等. 改良负压封闭引流术治疗口腔颌面部间隙感染的疗效和费用分析[J].中国实用护理杂志, 2016, 32(13): 1024-1027. [Liu QR, Shi L, Lu XH, et al. The clinical effect and cost analysis of patients of oral and maxillofacial space infection treated with improved closed negative pressure drainage[J]. Chinese Journal of Practical Nursing, 2016, 32(13): 1024-1027.]  DOI: 10.3760/cma.j.issn.1672-7088.2016.13.018.

21.丛丙峰, 丁明超, 许方方, 等. 144例颌面部间隙感染患者的流行病学分析[J]. 实用口腔医学杂志, 2016, 32(2): 212-215. [Cong BF, Ding MC, Xu FF, et al. An epidemiological analysis of 144 cases with maxillofacial space infection[J]. Journal of Practical Stomatology, 2016, 32(2): 212-215.] DOI: 10.3969/j.issn.1001-3733. 2016.02.012.

22.Decorte I, Van Campe W, Mostin L, et al. Diagnosis of the Lelystad strain of Porcine reproductive and respiratory syndrome virus infection in individually housed pigs: comparison between serum and oral fluid samples for viral nucleic acid and antibody detection[J]. J Vet Diagn Invest, 2015, 27(1): 47-54. DOI: 10.1177/1040638714561252.

23.刘洋, 江威, 韩伦英, 等. PCT、CRP、WBC和N%在细菌感染性疾病中的诊断价值评估[J]. 实用医学杂志, 2018, 34(4): 641-652. [Liu Y, Jiang W, Han LY, et al. Evaluation of PCT,CRP,WBC and N% in the diagnosis and treatment of common pathogenic bacteria[J]. The Journal of Practical Medicine, 2018, 34(4): 641-652.] DOI: 10.3969/j.issn.1006-5725.2018.04.030.

24.顾鹏, 王庆, 王璇, 等. 降钙素原在临床感染中的应用[J].药物流行病学杂志, 2018, 27(12): 833-837. [Gu P, Wang Q, Wang X, et al. The Application ofprocalcitonin in clinical infection[J]. Chinese Journal of Pharmacoepidemiology, 2018, 27(12): 833-837.] DOI: 10.19960/j.cnki.issn1005-0698.2018.12.013.

25.刘坤贺, 张春美. 血清降钙素原对革兰阴性或革兰阳性菌血流感染的诊断价值[J]. 临床肺科杂志, 2018, 23(4): 663-665. [Liu KH, Zhang CM. Diagnostic value of serum procalcitonin measurement for identification of gram-negative and gram-positive bacterial bloodstream infection[J]. Journal of Clinical Pulmonary Medicine, 2018, 23(4): 663-665.] DOI: 10.3969/j.issn.1009-6663. 2018.04.022.

26.于宏伟, 程阔, 马伟立, 等. 降钙素原、C-反应蛋白在鉴别血流感染菌属中的应用价值[J]. 中国免疫学杂志, 2018, 34(2): 243-246. [Yu HW, Cheng K, Ma WL, et al. Value of procalcitonin and C-reactive protein in discriminating bloodstream infection bacterial species[J]. Chinese Journal of Immunology, 2018, 34(2): 243-246.] DOI: 10.3969/j.issn.1000-484X.2018.02.017.

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