A 53-year-old male patient with hepatocellular carcinoma, liver cirrhosis, and peritoneal lymph node metastasis was admitted due to upper gastrointestinal bleeding. During gastrointestinal endoscopy, esophageal and gastric variceal bleeding was observed, and 2 mL of lauromacrogol injection was injected. One minute after injection, the patient suddenly developed tachycardia (140 beats per minute), hypotension (60/40 mmHg), oxygen saturation of 80%, and tachypnea, which were consistent with lauromacrogol-induced anaphylactic shock. The endoscopic procedure was immediately terminated, and anti-anaphylactic and anti-shock treatments were administered promptly, leading to rapid reversal of the shock symptoms. On the 3rd day of hospitalization, another endoscopy was performed without lauromacrogol injection, and no allergic reaction occurred. Using Naranjo's Assessment Scale to evaluate the association between lauromacrogol injection and anaphylactic shock, a score of 7 points was obtained, indicating a probable association. To date, there have been no published reports in domestic literature regarding adverse reactions associated with anaphylactic shock following administration of lauromacrogol injection. This article presents a case of anaphylactic shock with lauromacrogol injection, aiming to raise the awareness of medical professionals about the potential adverse reactions associated with lauromacrogol injection.

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