Acute pancreatitis caused by bortezomib in multiple myeloma: a case report and literature review

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Author: Liang YANG ¹ Zhen ZENG ¹ Chuan-Cui LUO ¹ Ling JIANG ¹ Xiu-Jun LI ²  Xun-Rong ZHOU ¹

Affiliation: 1. Department of Pharmacy, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China 2. Department of Hematology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China

Keywords: Bortezomib Acute pancreatitis Multiple myeloma Adverse drug reaction

DOI: 10.19960/j.issn.1005-0698.202301014

Reference: Liang YANG, Zhen ZENG, Chuan-Cui LUO, Ling JIANG, Xiu-Jun LI, Xun-Rong ZHOU.Acute pancreatitis caused by bortezomib in multiple myeloma: a case report and literature review[J].Yaowu Liuxingbingxue Zazhi,2023, 32(1): 99-102.DOI: 10.19960/j.issn.1005-0698.202301014.[Article in Chinese]  Copied

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Abstract

A case of adverse drug reaction caused by bortezomib in the treatment of acute pancreatitis (AP) in patients with multiple myeloma (MM) was reported. Combined with related literature and similar cases in the FDA adverse event reporting system (FAERS), the characteristics and prevention points of this kind of ADR were summarized and analyzed. It is recommended that when MM patients, especially elderly patients (age≥60 years old) are given bortezomib treatment, the occurrence of AP should be highly alert to, when upper abdominal pain occurs, it should be combined with relevant laboratory tests. Identify and treat symptomatically as soon as possible to avoid greater harm to patients.

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